Synonym name: Crategolic acid; Crataegolic acid
Catalogue No.: BP0926
Cas No.: 4373-41-5
Formula: C30H48O4
Mol Weight: 472.71
Botanical Source: From many spp. including Crataegus oxycantha and Chamaenerion angustifolium
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams,customized for large scale(Upto Kgs scale, for 90%, 95% upto Ton).
Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative agent against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).
Maslinic acid‘s antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages.Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.
References:
1, Maslinic acid from olives shows anti-cancer properties
THE MEDICAL NEWS Feb 14 2008
2, Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway.
Cancer Lett. 2009 Jan 8;273(1):44-54. Epub 2008 Sep 14.
HPLC of Maslinic acid
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
