| Catalog No | Package | Original Price | Price | Inventory | Quantity | Operating |
|---|---|---|---|---|---|---|
| BP0511-20mg | 20mg | $30.00 | Sign in |
|
Product name: Catechin hydrate
Synonym name: (+)-Catechin hydrate
Catalogue No.: BP0511
Cas No.: 225937-10-0
Formula: C15H14O6·xH2O
Mol Weight: 290.271(anhydrous basis)
Botanical Source: Green Tea
Physical Description:
Type of Compound: Polyphenols
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
Catechin hydrate, as an important natural polyphenolic compound, has attracted widespread attention in the field of natural product pharmacology in recent years due to its significant biological activity and potential medicinal value. Catechins are widely present in various plants, especially in tea, which is rich in content and has good antioxidant, anti-inflammatory, anti-tumor, and cardiovascular protective effects. Hydrated catechins, as the hydrated form of catechins, exhibit excellent inhibition of cyclooxygenase-1 (COX-1) activity with an IC50 value of 1.4 μ M, demonstrating strong anti-inflammatory potential. In addition, hydrated catechins exhibit excellent cell protective ability in antioxidant damage by regulating various antioxidant related targets, such as NFE2L2 (NRF2), SOD1, CAT, GPX1, HMOX1, and SOD2. This article provides a systematic review of the chemical structure and physicochemical properties, plant sources and extraction methods, pharmacological activity, mechanism of action, pharmacological evaluation, and clinical application prospects of hydrated catechins. The aim is to provide theoretical basis and reference for further research and development of this compound.
The chemical name of hydrated catechins is (2R, 3S) -3,3 ', 4', 5,7-pentahydroxyflavan-3-ol, with a molecular formula of C15H14O6 and a molecular weight of 290.2710. Its CAS number is 225937-10-0. Hydrated catechins belong to flavan-3-ol compounds, which contain multiple hydroxyl groups in their structure, endowing them with good hydrophilicity and antioxidant activity. Its physicochemical properties show a LogP value of 0.9710, indicating moderate lipid solubility and favorable bioavailability in vivo. The polar surface area (TPSA) is 110.38 Å ², reflecting its high molecular polarity, which may affect its cell membrane penetration ability. The water solubility is 0.7536, indicating that it has a certain solubility in water, which is helpful for the development of formulations and in vivo absorption. The low permeability of the blood-brain barrier suggests that its role in the central nervous system may be limited. The negative result of hERG channel inhibition experiment indicates a low risk of cardiac toxicity. The Ames test result is 0.0, indicating that hydrated catechins have no significant genotoxicity.
Hydrated catechins are widely present in various plants, especially abundant in tea (Camellia sinensis) and its products. In addition to tea, hydrated catechins can also be detected in certain fruits, nuts, and medicinal plants. It is mainly extracted using water or alcohol solvents, and obtained through techniques such as leaching, ultrasound assisted extraction, or microwave-assisted extraction. In recent years, green extraction technologies such as supercritical fluid extraction and enzyme assisted extraction have been gradually applied to improve extraction efficiency and purity while reducing environmental pollution. After extraction, purity analysis and structural identification are often performed using liquid chromatography (HPLC) and mass spectrometry techniques. During the purification process, reverse phase high-performance liquid chromatography (RP-HPLC) is a commonly used separation method that can effectively separate hydrated catechins from other structurally similar isomers of catechins.
The pharmacological activities of hydrated catechins are mainly reflected in antioxidant, anti-inflammatory, anti-tumor, and cardiovascular protection aspects.
antioxidant activity
Hydrated catechins significantly alleviate oxidative stress damage by clearing free radicals, inhibiting lipid peroxidation, and enhancing endogenous antioxidant enzyme activity. In vitro studies have shown that hydrated catechins can activate the NFE2L2/NRF2 signaling pathway, promote the expression of downstream antioxidant enzymes such as SOD1, CAT, GPX1, and HMOX1, thereby enhancing cell resistance to oxidative damage.
anti-inflammatory effect
Hydrated catechins exhibit potent inhibitory effects on cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μ M, indicating their potential anti-inflammatory activity. COX-1 is a key enzyme in prostaglandin synthesis, involved in inflammatory response and gastrointestinal protection. Hydrated catechins alleviate inflammation by inhibiting COX-1 activity, while having relatively fewer side effects due to their high selectivity.
antitumor activity
Some studies have shown that hydrated catechins can exert anti-tumor effects by inducing cancer cell apoptosis, inhibiting tumor cell proliferation and migration. Its mechanism involves regulating cell cycle related proteins, activating apoptotic signaling pathways, and inhibiting the tumor associated inflammatory microenvironment.
Cardiovascular protection
Hydrated catechins have a protective effect on cardiovascular disease by improving endothelial function, reducing blood lipids, and inhibiting platelet aggregation through antioxidant and anti-inflammatory effects. Its regulation of vasodilators such as nitric oxide (NO) further enhances its cardiovascular protective effect.
The multi-target mechanism of action of hydrated catechins mainly involves two aspects: antioxidant and anti-inflammatory
Antioxidant mechanism
Hydrated catechins activate the NFE2L2/NRF2 signaling pathway, promote the expression of antioxidant enzyme genes, and enhance intracellular antioxidant capacity. NFE2L2, as a key transcription factor in cells, regulates the expression of antioxidant enzymes such as SOD1, CAT, GPX1, HMOX1, and SOD2 to resist cellular damage caused by oxidative stress. In addition, hydrated catechins directly scavenge free radicals, reduce ROS accumulation, and protect cell membrane lipids from oxidation.
Anti inflammatory mechanism
Hydrated catechins inhibit COX-1 activity, reduce prostaglandin synthesis, and decrease the release of inflammatory mediators. COX-1 inhibitors are often associated with gastrointestinal side effects, but the selective inhibition of hydrated catechins and their natural sources may make them safer anti-inflammatory candidate compounds. In addition, hydrated catechins may also exert anti-inflammatory effects by inhibiting the NF - κ B signaling pathway, reducing the expression of pro-inflammatory cytokines such as TNF - α and IL-6.
Other targets and signaling pathways
Research also suggests that hydrated catechins may affect signaling pathways such as MAPK and PI3K/Akt, regulate cell apoptosis and proliferation processes, and participate in anti-tumor and cell protective effects.
The pharmacological parameters of hydrated catechins indicate that they have certain potential for drug development. The molecular weight is 290.2710, which conforms to Lipinski's rule. The LogP value is 0.9710, indicating that it has moderate lipid solubility and is conducive to absorption and distribution in vivo. The TPSA is 110.38 Å ², indicating moderate polarity that may affect oral bioavailability and cell membrane penetration. The water solubility is 0.7536, which is suitable for the development of water-based formulations.
The low permeability of the blood-brain barrier limits its application in central nervous system diseases, but also reduces the risk of central nervous system toxicity. The hERG channel inhibition experiment was negative, indicating a low risk of cardiac toxicity and good safety. The Ames test result is 0.0, indicating no significant genotoxicity and meeting drug safety requirements.
In terms of pharmacokinetics, the oral absorption of hydrated catechins is relatively fast, but due to their high polarity, their bioavailability may be limited. The metabolism in the body is mainly carried out through the liver enzyme system, and the metabolites are mostly glucosinolates and sulfate complexes. Its half-life is moderate and suitable for daily administration. In the future, further research is needed on its in vivo distribution, metabolic kinetics, and excretion pathways to optimize the dosing regimen.
Hydrated catechins, as a naturally occurring polyphenolic compound, exhibit significant antioxidant and anti-inflammatory activities, demonstrating broad clinical application prospects. Its potential therapeutic value in chronic inflammatory diseases such as arthritis, cardiovascular disease, and metabolic syndrome has attracted much attention. Due to its good safety and low toxicity, hydrated catechins are expected to serve as adjunctive therapeutic agents, reducing the side effects of traditional drugs.
In addition, the application of hydrated catechins in antioxidant injury related diseases is also of great significance, such as neurodegenerative diseases, diabetes and liver diseases. It enhances cellular antioxidant defense and may slow down disease progression by regulating the NFE2L2/NRF2 pathway.
In the future, with in-depth research on the pharmacological mechanism of hydrated catechins and the development of clinical trials, their potential as a new natural medicine or health product will be further revealed. By combining nanotechnology and drug delivery systems, it is expected to improve its bioavailability and targeting, and expand its clinical application scope.
Hydrated catechins, as an important natural polyphenolic compound, have demonstrated excellent pharmacological effects and medicinal potential due to their significant antioxidant and anti-inflammatory activities. It exerts a cell protective effect by regulating intracellular oxidative stress and inflammatory response through multiple targets and pathways. The physicochemical properties and safety evaluation support its development as a candidate drug. In the future, it is necessary to strengthen systematic research on its pharmacokinetic characteristics and clinical efficacy, and promote its application and transformation in various diseases. In summary, hydrated catechins are a highly promising natural product drug that deserves further exploration and utilization in the fields of natural medicine development and disease treatment.
