Product name: Ginsenoside Rb2
Synonym name: Ginsenoside
Catalogue No.: BP0658
Cas No.: 11021-13-9
Formula: C53H90O22
Mol Weight: 1079.28
Botanical Source: Panax ginseng (ginseng) and Panax notoginseng
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments; ginsenoside Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.[1]
Ginsenoside Rb2 is a inducer of the SOD1 gene, the SOD1 gene is greatly activated by ginsenoside Rb2 through transcription factor AP2 binding sites and its induction.[2]
The intra-tumoral or oral administration of ginsenoside-Rb2 causes a marked inhibition of both neovascularization and tumor growth,the inhibition of tumor-associated angiogenesis by ginsenoside-Rb2 may partly contribute to the inhibition of lung tumor metastasis.[3]
Ginsenoside-Rb2 has hypoglycemic activity in streptozotocin-diabetic rat, one of the mechanisms probably is the changes of glucokinase and glucose-6-phosphatase levels.
Ginsenoside-Rb2 has anti-oxidant activity, has hydroxyl radical scavenging activity changes by heat processing.[4]
Ginsenoside Rb2 can enhance the expression of the sterol regulated element binding protein (SREBP) mRNA whereas treatment with cholesterol and FBS led to a reduction in the abundance of this transcript, suggests that it might be a valuable component capable of lowering the levels of lipids.[5]
Ginsenoside-Rb2 is the most effective among ginsenosides from red ginseng to prevent the lethal infection of HVJ, so that this ginsenoside is a promising candidate as a mucosal immunoadjuvant to enhance antiviral activity.[6]
References:
[1] Lee K T, Jung T W, Lee H J, et al. Arch Pharm Res, 2011, 34(7):1201-8.
[2] Kim Y H, Park K H, Rho H M. J Biol Chem, 1996, 271(40):24539-43.
[3] Sato K, Mochizuki M, Saiki I, et al. Biol Pharm Bull, 1994, 17(5):635-9.
[4] Kang K S, Kim H Y, Baek S H, et al. Biol Pharm Bull, 2007, 30(4):724-8.
[5] Kim E J, Lee H I, Chung K J, et al. Bmb Rep, 2009, 42(4):194-9.
[6] Yin S, Wu H, Xu F, et al. Acta Acad Med Militaris Tertiae, 2010, 32(7):658-60.
[7] Yoo Y C, Lee J, Park S R, et al. J Ginseng Res, 2013, 37(1):80-6.
HPLC of Ginsenoside Rb2
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
357.0600
2.0515
2.0515
.1605
.4702
.0981
Low
70.7396
6.8267
Yes
No
No
No
No
No
0.0
Yes
No
No
No
