Product name: Ophiopogonin B
Synonym name: Prosapogenin D3
Catalogue No.: BP1034
Cas No.: 38971-41-4
Formula: C39H62O12
Mol Weight: 722.913
Botanical Source: Ophiopogon japonicus and Liriope spicata
Physical Description: Powder
Type of Compound: Steroids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ophiopogonin B (OP-B) is a bioactive component of Radix Ophiopogon Japonicus, which is often used in Chinese traditional medicine to treat pulmonary disease, it is a prospective inhibitor of PI3K/Akt and may be used as an alternative compound to treat NSCLC, it also induces apoptosis, mitotic catastrophe and autophagy , has inhibitory effect on adhesion, invasion and migration of A549 cells in vitro.[1-3]
Ophiopogonin B increases the protein expression levels of caspase-3 and B-cell lymphoma 2 (Bcl-2)-associated X protein, whereas the expression levels of Bcl-2 and the phosphorylation levels of extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinases 1/2 were decreased suggests that it may be considered a potential inhibitor of gastric cancer progression, and may be used as an alternative compound for its treatment.[4]
References:
[1] Chen M, Du Y, Qui M, et al. Oncol Rep, 2013, 29(2):430-6.
[2] Chen M, Guo Y, Zhao R, et al. Int J Oncol, 2016,49(1):316-24.
[3] Chen M J, Zhao R L, Guo Y Y, et al. Chinese Pharmacol Bull, 2015, 31(5):660-4.
[4] Zhang W, Zhang Q, Jiang Y, et al. Mol Med Rep, 2016, 13(6):4981-6.
[5] Wu T, Yu B Y, Cheng Z H , et al.Chinese herbal medicine, 2000, 31 (03): 175-7.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
