Product name: Alpha-Hederin
Synonym name:
Catalogue No.: BP0154
Cas No.: 27013-91-8
Formula: C41H66O12
Mol Weight: 750.967
Botanical Source: Hedera helix; Chinese ivy; Hedera nepalensis K,Koch var.sinensis (Tobl.) Rehd
Physical Description: Powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Alpha-hederin as a pro-drug, has cytotoxic and apoptotic/necrotic effects in a dose- and time-dependent manner on on four human cancer cell lines [A549 (lung carcinoma), HEp-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) and MIA PaCa-2 (pancreas carcinoma)] .[1]
Alpha-hederin is a saponin isolated from ivy, has anti-oxidant activity and acute anti-inflammatory activity in carrageenan-induced rat paw edema.[2]
Alpha-hederin, chlorophyllin and ascorbic acid have protective effects towards the induction of micronuclei by doxorubicin in cultured human lymphocytes.[3]
Alpha-hederin has antileishmanial activity ,exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential in Leishmania .[4]
Alpha-hederin affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.[5]
Alpha-Hederin can increase isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like .[6]
Alpha-hederin at sub-IC(50) cytotoxic concentrations enhances 5-fluorouracil (5-FU) cytotoxicity about 3.3-fold, suggests that it is possible to optimize colorectal cancer cell sensitivity to 5-FU with alpha-hederin.[7]
Alpha-hederin has anticancer effect on breast cancer cells.[8]
References:
[1] Rooney S, Ryan M F. Anticancer Res, 2005, 25(3B):2199-204.
[2] Gepdiremen A, Mshvildadze V, S?leyman H, et al. Phytomedicine, 2005, 12(6-7):440-4.
[3] Gül?in I, Mshvildadze V, Gepdiremen A,et al. Planta Med, 2004, 70(6):561-3.
[4] Amara-Mokrane Y A, Lehucher-Michel M P, Balansard G, et al. Mutagenesis, 1996, 11(2):161-7.
[5] Delmas F, Di G C R, Gasquet M, et al. Planta Med, 2000, 66(4):343-7.
[6] Sieben A, Prenner L, Sorkalla T, et al. Biochemistry, 2009, 48(15):3477-82.
[7] Anne Wolf, Reinoud Gosens, Herman Meurs, et al. Phytother Res Ptr, 2008, 22(10):1299-302.
[8] Cheng L, Xia T S, Wang Y F, et al. Int J Oncol, 2014, 45(2):757-63.
[9] Li Y, Li J, Huang J, et al. Chinese Agr Sci Bull, 2014, 30(13):190-3.
HPLC of Alpha-Hederin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
