Product name: Ginsenoside F2
Synonym name:
Catalogue No.: BP0654
Cas No.: 62025-49-4
Formula: C42H72O13
Mol Weight: 785.025
Botanical Source: Panax spp.
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenoside F2 has the anti-cancer activity, it induces apoptosis in breast cancer stem cells (CSCs) by activating the intrinsic apoptotic pathway and mitochondrial dysfunction, also induces the formation of acidic vesicular organelles, recruitment of GFP-LC3-II to autophagosomes, and elevation of Atg-7 levels, suggests that F2 initiates an autophagic progression in breast CSCs. [1]
Ginsenoside F2 suppresses hair cell apoptosis and premature entry to catagen more effectively than finasteride, it decreases the expression of TGF-β2 and SCAP proteins, this study provides evidence those factors in the SCAP pathway could be targets for hair loss prevention drugs.[2]
Ginsenoside F2 could be a new potential chemotherapeutic drug for glioblastoma multiforme (GBM) treatment by inhibiting the growth and invasion of cancer, the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8.[3]
Ginsenoside F2 may reduce obesity via the inhibition of adipogenesis in the 3T3-L1 cell line.[4]
References:
[1] Mai T T, Moon J Y, Song Y W, et al. Cancer Lett, 2012, 321(2):144–53.
[2] Shin H S, Park S Y, Hwang E S, et al. Biol Pharm Bull, 2014, 37(5):755-63.
[3] Shin J Y, Lee J M, Shin H S, et al. J Ginseng Res, 2012, 36(1):86-92.
[4] Siraj F M, Sathishkumar N, Kim Y J, et al. J Enzym Inhib Med Ch, 2014, 30(1):9-14.
[5] Zhou W, Li J, Li X, et al. J Sep Sci, 2008, 31(6-7):921-5.
HNMR of Ginsenoside F2
HPLC of Ginsenoside F2
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
218.9900
3.2616
3.2613
.0317
.5922
.1896
Low
77.7256
5.8834
No
No
No
No
No
No
0.0
Yes
No
No
No
