Product name: Ginsenoside Rg2
Synonym name: Chikusetsusaponin I; Ginsenoside C
Catalogue No.: BP0665
Cas No.: 52286-74-5
Formula: C42H72O13
Mol Weight: 785.025
Botanical Source: Panax ginseng (ginseng), Panax quinquefolia and Panax notoginseng
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenoside Rg2 suppresses the hepatic glucose production via AMPK-induced phosphorylation of GSK3β and induction of SHP gene expression, suggests that it has therapeutic potential for type 2 diabetic patients.[1]
Ginsenoside Rg2 inhibits nicotinic acetylcholine receptor-mediated Na+ influx and channel activity; it also inhibits the 5-HT-induced inward peak current (I5-HT) in dose dependent and reversible manner, the half-inhibitory concentrations (IC50) of ginsenoside Rg2 is 22.3 +/- 4.6 microM, suggests that it might regulate the 5-HT3A receptors that are expressed in Xenopus oocytes.[2]
Ginsenoside Rg2 can reduce LPS-mediated THP-1 monocyte adhesion to HUVEC, in a concentration-dependent manne, it may provide direct vascular benefits with inhibition of leukocyte adhesion into vascular wall thereby providing protection against vascular inflammatory disease.[3]
Ginsenoside Rg2 protects cells against UVB-induced genotoxicity by increasing DNA repair, in possible association with modulation of protein levels involved in p53 signaling pathway.[4]
Ginsenoside Rg2 improves learning and memory through mechanisms related to anti-apoptosis in MID rats, indicates that it may represent a potential neurorestorative treatment strategy for vascular dementia or other ischemic insults.[5]
Ginsenoside Rg2 has protective effects against H2O2-induced injury and apoptosis in H9c2 cells.[6]
References:
[1] Yuan H D, Kim D Y, Quan H Y, et al. Chem-Bioll Interact, 2012, 195(1):35-42.
[2] Choi S, Lee J H, Oh S, et al. Mol Cells, 2003, 15(1):108-13.
[3] Cho Y S, Chan H K, Ha T S, et al. Korean J Physiol Pham 2013, 17(2):133-7.
[4] Ha S E, Shin D H, Kim H D, et al. N-S Arch Pharmacol, 2010, 382(1):89-101.
[5] Gong Z H, Liu M X, Gong L L, et al. Prog in Modern Biomed, 2010,10(06):1069-75.
[6] Fu W, Sui D, Yu X, et al. Int J Clin Exp Med, 2015, 8(11):19938-47.
[7] Yu M, Mi H, Jiao L. China Pharmacist, 2005, 8(12):1017-9.
HPLC of Ginsenoside Rg2
HNMR of Ginsenoside Rg2
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
218.9900
3.1018
3.1014
.0429
.6108
.2027
Low
67.0258
6.0007
No
No
No
No
No
No
0.0
Yes
No
No
No
