Product name: Imperatorin
Synonym name: Marmelide; Ammidin; Marmelosin
Catalogue No.: BP0761
Cas No.: 482-44-0
Formula: C₁₆H₁₄O₄
Mol Weight: 270.284
Botanical Source: Present in roots of Imperatoria ostruthium and Clausena dentata. Also in Aegle marmelos, Angelica dahurica, Glehnia littoralis infected with Pseudomonas cichorii, Ammi majus, Pastinaca spp., Seseli campestre, Urena lobata and others
Physical Description: Cryst.
Type of Compound: Coumarins

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Imperatorin, a biologically active furanocoumarin from the roots of Angelica dahurica (Umbelliferae), can induce apoptosis in human promyelocytic leukaemia, HL-60 cells,
and induces apoptosis was significantly blocked by Z-VAD-FMK (a broad spectrum caspase inhibitor), Z-LEHD-FMK (a caspase-9 inhibitor) and Ac-DMQD-CHO (a caspase-3 inhibitor), but not by Z-IEDT-FMK (a caspase-8 inhibitor).[1]
Imperatorin and quercetin are potent apoptosis inducers, especially when they act synergistically, which may be a promising combination useful in glioma therapy, it also blocks the HSP27 and HSP72 gene expression might serve as a therapeutic target for the human brain cancer.[2]
Imperatorin has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases, it exerts considerable anti?proliferative activities in HT?29 colon cancer cells and highlight the potential of imperatorin as an anticancer agent for colon cancer.[3]
Imperatorin exerts anti-inflammatory activity, also has effects on inhibition of degranulation and eicosanoid generation through the suppression of multiple steps of IgE/Ag-mediated signaling pathways would be beneficial for the prevention of allergic inflammation.[4]
Imperatorin has anticonvulsant effects, dampens neuronal excitability by inhibiting voltage-gated Na + channels (VGSC).[5]

References:
[1] Pae H O, Oh H, Yun Y G, et al. Pharm Toxicol, 2002, 91(1):40–48.
[2] Wu K C, Chen Y H, Cheng K S, et al. Eur J Pharmacol, 2013, 721(1–3):49-55.
[3] Zheng Y M, Lu A X, Shen J Z, et al. Oncol Rep, 2016.
[4] D B?dziul, Jakubowicz-Gil J, Langner E, et al. Pharmacol Rep , 2014, 66(2):292-300.
[5] Jeong K T, Lee E, Park N Y, et al. Biomol Ther, 2015, 23(5):421-7.
[6] Xue J, Ping W, Yang W, et al. Chemistry & Industry of Forest Products, 2008, 28(3):101-3.

HPLC of  Imperatorin

HNMR of  Imperatorin

Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃