Product name: Ginsenoside CK
Synonym name: Ginsenoside C-K; Ginsenoside Compound k
Catalogue No.: BP0651
Cas No.: 39262-14-1
Formula: C36H62O8
Mol Weight: 622.884
Botanical Source: Prod. from saponins of Gynostemma pentaphyllum by endogenous glycosidases
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 50%, 90%, 95%, 99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenoside compound K (C-K) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes; C-K acts as a unique HUVEC migration inhibitor by regulating MMP expression, as well as the activity of SPHK1 and its related sphingolipid metabolites.[1]
Ginsenoside compound K, the intestinal metabolite of ginseng saponin, has various chemopreventive and chemotherapeutic activities, including anti-tumor activity; C-K suppresses the activation of the NF-κB pathway, may become a potential cytotoxic drug in the prevention and treatment of hepatocellular carcinoma( HCC).[2]
Ginsenoside compound K shows significant anti-proliferative effects and pro
-apoptotic effects in HCT-116 and SW-480 cells at concentrations of 30-50 uM, suggests that C-K could be potentially effective anti-colorectal cancer agent.[3]
Ginsenoside CK has anti-cancer effect on NPC cells, C-K-induced apoptosis of HK-1 cells was mediated by the mitochondrial pathway and could significantly inhibit tumor growth in vivo.[4]
Ginsenoside Compound K is one of the main bioactive components of ginseng that is obtained from bio-conversion of ginseng saponin using microorganism fermentation. Researches have indicated that Compound K delivers powerful, anti-aging benefits, including: fighting active oxygen and free radicals, promoting collagen synthesis and elastase inhibition, reducing the appearance of wrinkles, and improving skin elasticity and firmness. Its extremely low solubility and hydrophobic properties have prevented this potent ingredient from being effectively used in skincare formulas. With our solubilization technology, we are able to water-solubilize Compound K and effectively use it as one of our key ingredients in our hero product, Age-Reversing All-In-One Concentrate.
References:
[1] Shin K O, Seo C H, Cho H H, et al. Arch Pharm Res, 2014, 37(9):1183-92.
[2] Ming Y, Chen Z, Chen L, et al.Planta Med, 2011, 77(5):428-33.
[3] Wang C Z, Du G J, Zhang Z, et al.Int J Oncol , 2012, 40(6):1970-6.
[4] Law K M, Kwok H H, Poon P Y, et al. Chinese Medicine, 2014, 9(1):1-9.
[5] Zhou W, Luo Z S, Zhou P, et al. Chromatogram, 2005, 23(3):270-2.
HNMR of Ginsenoside CK
HPLC of Ginsenoside CK
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
