Product name: 2-Acetylacteoside
Synonym name:
Catalogue No.: BP0047
Cas No.: 94492-24-7
Formula: C31H38O16
Mol Weight: 666.629
Botanical Source: Cistanches herba
Physical Description:
Type of Compound: Phenylpropanoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，TCM), Natural Active Pharmaceutical Ingredients worldwide.
The main services:
A. Supply active ingredients and reference standards of TCM, from mgs to kgs scale
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR(contract research), CM(contract manufacture) and PD(process development) services from lab scale, pilot scale to commercial scale(GMP is also available)
E. TCM compounds library for drug screen,more than 3000 compounds available, many of them are rare and unique.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
260.6700
-2.0000
-2.5000
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Unknown
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Natural products, as important resources for drug discovery, play a crucial role in the field of new drug development due to their structural diversity and rich biological activity. In recent years, glycoside compounds have become a hot topic in natural product pharmacology research due to their wide biological activity and relatively low toxicity and side effects. 2 '- Acetyl verbascoside (CAS number: 94492-24-7), as a specific glycoside natural product, has gradually attracted attention from the scientific community due to its unique structure and potential pharmacological activity. This article aims to systematically review the chemical structure, plant origin, pharmacological activity, and mechanism of action of 2 '- acetyl verbascoside, and explore its clinical application prospects in combination with pharmacological parameters, providing a theoretical basis and reference for subsequent research.
2 '- Acetyl verbascoside is a phenolic glycoside compound with a molecular weight of 662.6400, a complex molecular formula, and multiple hydroxyl and ester groups. Its structural characteristics include a core of verbascoside, with acetyl modification at the 2 'position, giving it unique physicochemical properties. The LogP value of this compound is -2.0000, indicating its high hydrophilicity and good water solubility, making it suitable for in vivo distribution and metabolic processes. The TPSA (topological polar surface area) is as high as 260.67 Å ², indicating strong molecular polarity that may affect its cell membrane permeability and bioavailability. The molecule contains 16 hydrogen bond acceptors, indicating that it has abundant hydrogen bonding sites when binding with biomolecules.
From the perspective of drug safety, 2 '- acetyl verbascoside does not have the ability to penetrate the blood-brain barrier, reducing the risk of central nervous system toxicity and side effects. Hepatotoxicity, cardiotoxicity, and hERG channel inhibition were not observed, indicating good safety. However, the mutagenicity of Ames is not yet clear and further genetic toxicology research is needed.
2 '- Acetyl verbascoside is mainly present in various plants of the family Ranunculaceae, especially in the leaves and stems of certain medicinal plants such as Phlomis spp. and related species. It has a wide natural distribution, and its content in the plant body is significantly affected by the growth environment, harvesting time, and extraction process.
Common extraction methods include solvent extraction and chromatographic separation techniques. Generally, ethanol or methanol is used as the extraction solvent, and the extraction efficiency is improved by ultrasound assisted extraction or reflux extraction. The extract was concentrated, liquid-liquid partitioned, and purified by multi-stage column chromatography (such as silica gel column, reverse phase C18 column) to obtain high-purity 2 '- acetyl verbascoside. In recent years, the application of supercritical fluid extraction and membrane separation technology has further optimized the extraction process, improved yield and purity.
The pharmacological activity research of 2 '- acetyl verbascoside mainly focuses on its anti-inflammatory, antioxidant, anti-tumor, and neuroprotective aspects.
anti-inflammatory effect
In vitro cell models and animal experiments have shown that 2 '- acetyl verbascoside can significantly inhibit the expression of pro-inflammatory factors such as TNF - α, IL-1 β, and IL-6, and alleviate inflammatory responses. It exhibits good anti-inflammatory effects by regulating the NF - κ B signaling pathway and inhibiting the release of inflammatory mediators.
antioxidant activity
This compound has the ability to scavenge free radicals and reduce oxidative stress levels. The DPPH radical scavenging assay and intracellular ROS detection both showed significant antioxidant effects, which help protect cells from oxidative damage.
Antitumor potential
Preliminary in vitro cell experiments have shown that 2 '- acetyl verbascoside has inhibitory effects on proliferation and induces apoptosis in various tumor cell lines. The mechanism may involve regulating the expression of cell cycle proteins and apoptosis related proteins, but the specific targets and signaling pathways need further clarification.
Neuroprotective effect
Although its blood-brain barrier penetration ability is limited, some studies have shown that 2 '- acetyl verbascoside exhibits neuroprotective effects in peripheral nerve injury models, which may alleviate nerve damage through anti-inflammatory and antioxidant mechanisms.
The mechanism of action of 2 '- acetyl verbascoside involves multiple cellular signaling pathways and molecular targets:
NF - κ B signaling pathway
As a key inflammatory regulatory factor, NF - κ B plays a central role in various inflammatory and immune responses. 2 '- Acetyl verbascoside inhibits the phosphorylation and degradation of I κ B α, blocks the nuclear translocation of NF - κ B, and reduces the transcriptional activity of pro-inflammatory genes.
MAPK signaling pathway
This compound can regulate the activity of MAPK family members such as p38, ERK, and JNK, thereby affecting cell proliferation, differentiation, and apoptosis processes.
Regulation of antioxidant related enzymes
2 '- Acetyl verbascoside can activate the Nrf2 ARE signaling pathway, promote the expression of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPx), and enhance the antioxidant defense ability of cells.
Regulation of apoptosis related proteins
In tumor cells, this compound regulates the expression ratio of Bcl-2 family proteins and promotes cell apoptosis. Its activation of Caspase-3 and Caspase-9 further confirms its ability to induce programmed cell death.
From the perspective of pharmacological parameters, 2 '- acetyl verbascoside has the following characteristics:
At present, there is a lack of pharmacokinetic data on it, and a systematic study of its absorption, distribution, metabolism, and excretion (ADME) characteristics is needed, especially parameters such as oral bioavailability and in vivo half-life, to guide preclinical drug development.
Based on its significant anti-inflammatory and antioxidant activities, 2 '- acetyl verbascoside has potential therapeutic value in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease, as well as oxidative stress-related diseases such as cardiovascular disease and metabolic syndrome. In addition, its anti-tumor activity provides new ideas for adjuvant therapy of tumors.
However, due to pharmacokinetic defects such as high molecular weight, strong polarity, and low bioavailability, the clinical translation of 2 '- acetyl verbascoside still faces challenges. Future research should focus on:
2 '- Acetyl verbascoside, as a natural glycoside compound with multiple biological activities, has shown broad application prospects in anti-inflammatory, antioxidant, and anti-tumor fields. Its unique chemical structure endows it with rich pharmacological activity, but at the same time, it also brings challenges in drug development. In the future, through the combination of structural optimization and advanced drug delivery technology, it is expected to overcome its pharmacokinetic limitations and achieve clinical translation. The mechanism research and safety evaluation of the system will provide a solid scientific basis for its drug development, promote the development of natural product pharmacology, and facilitate the discovery and application of new natural medicines.
