Product name: Ginsenoside Rb1
Synonym name: Sanchinoside E1; Gypenoside III; Gynosaponin C
Catalogue No.: BP0657
Cas No.: 41753-43-9
Formula: C54H92O23
Mol Weight: 1109.31
Botanical Source: Panax ginseng (ginseng), Panax uinquefolia and Panax notoginseng
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenosides, a class of ginseng compounds of herbal medicine, have therapeutic potential for the neuroprotection of brain damage after cerebral ischemia because of their anti-oxidant and anti-inflammation activities, ginsenoside Rb1 could represent promising applications as anti-oxidants for the anti-aging treatment of neurological disorders, such as stroke, in elderly patients.[1]
Ginsenoside Rb1 presents cardioprotective effect against I/R or H/R injury which involves in activating Akt, phosphorylating GSK-3β and inhibiting mPTP opening.[2]
Ginsenoside Rb1 has anti-oxidative effects on NPCs, may offer potential as a potent antioxidant for the treatment of neurological disorders.[3]
Ginsenoside Rb1 possesses protective effects on swimming exercise-induced oxidative stress in mice.[4]
Ginsenosides Rb1 and Rg1 have many molecular targets including the (CREB), which is involved in melanogenesis, they increase melanogenesis and activity in melanocytes by the activation of PKA/CREB/MITF Signaling.[5]
Ginsenoside Rb1, ginsenoside Rg1,and estrogen can significantly enhance OVA-specific IgG responses, lymphocyte proliferation and cytokines mRNA expression and the enhancement could be blocked by pre-injection of an estrogen receptor antagonist ICI 182780, indicating that ginsenoside Rb1, ginsenoside Rg1, and estrogen may exhibit the adjuvant activities through estrogen receptors.[6]
References:
[1] Xiao D, Lei Z, Lu S, et al. Geriatr Gerontol In, 2015,12(1).
[2] Yu-hong Li , Yan-yan Li , Guan-wei Fan, et al. Chin J Integr Med, 2016:1-10.
[3] Ye J, Yao J P, Wang X, et al. Mol Med Rep, 2016, 13(4):3083-91.
[4] Qi B, Zhang L, Zhang Z, et al. Pharmacogn Mag , 2014, 10(40):458-63.
[5] Lin M, Zhang B X, Zhang C, et al. Evid-Based Compl Al, 2014, 2014(14):892073.
[6] Li Y, Wu L, Yuan L, et al. American Journal of Traditional Chinese Veterinary Medicine, 2012,2(7):1-17.
[7] Li-Na J I, Feng W H, Wang Z M, et al. China journal of Chinese materia medica, 2013, 38(17):2798-802.
HPLC of Ginsenoside Rb1
HNMR of Ginsenoside Rb1
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
