Product name: Ginsenoside Rg1
Synonym name: Ginsenoside A2; Panaxoside A; Sanchinoside C1
Catalogue No.: BP0664
Cas No.: 22427-39-0
Formula: C42H72O14
Mol Weight: 801.024
Botanical Source: Panax ginseng (ginseng)
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenoside Rg1 is the main pharmacologically active compound of ginsenosides and has demonstrated pharmacological effects in the cardiovascular system, central nervous system and immune system; Rg1 has protective effect against Aβ25-35-induced toxicity in PC12 cells,might be through the insulin-like growth factor-I receptor (IGF-IR) and estrogen receptor (ER)signaling pathways.[1]
Ginsenoside Rg1 is often recommended for its antiaging effects,Rg1 supplementation improved the performance of aged mice in behavior test and significantly upregulated the expression of synaptic plasticity-associated proteins in hippocampus, including synaptophysin, N-methyl-D-aspartate receptor subunit 1, postsynaptic density-95, and calcium/calmodulin-dependent protein kinase II alpha, via promoting mammalian target of rapamycin pathway activation.[2]
Ginsenoside Rg1 increases the expression of the vascular endothelial growth factor (VEGF) mRNA and reduces expression of transforming growth factor beta (TGF-B) mRNA in wounded skin , suggests that Rg1 should be helpful for the promotion of wound healing.[3]
Ginsenoside Rg1 is a desirable agent for enhancing CD4+ T-cell activity, as well as the correction of Th1-dominant pathological disorders, which by increasing Th2 specific cytokine secretion and by repressing Th1 specific cytokine production.[4]
Ginsenoside Rg1 promotes proliferation, migration, adhesion and in vitro vasculogenesis.[5] Rg1 inhibits platelet activation via the inhibition of ERK pathway, and attenuates arterial thrombus formation in vivo.[6]
Ginsenoside Rg1 possesses the neuroprotective effects on inducing differentiation of ES cells into neurons in vitro via the GR-MEK-/2-K-signaling pathway.[7]
References:
[1] Chen W F, Zhou L P, Chen L, et al. Neurochem Int, 2013, 62(8):1065-71.
[2] Yang L, Zhang J, Zheng K, et al. Journals of Gerontology, 2014, 69(3):282-94.
[3] ???, ???, ???, et al. ??????????, 2010, 39(10):437-45.
[4] Lee E J, Ko E, Lee J, et al. Int Immunopharmaco, 2004, 4(4):235-44.
[5] Shi A W, Wang X B, Lu F X, et al. Acta Phamacol Sin, 2009, 30(3):299-306.
[6] Zhou Q, Jiang L, Xu C, et al. Thromb Res?, 2014, 133(1):57-65.
[7] Wu J, Pan Z, Cheng M, et al. Neurochem Int , 2012, 62(1):92-102.
[8] Jia G, Li M A, Han F. Journal of Tianjin University of Traditional Chinese Medicine, 2011(1):41-42.
HPLC of Ginsenoside Rg1
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
