Product name: Ginsenoside Re
Synonym name:
Catalogue No.: BP0662
Cas No.: 52286-59-6
Formula: C48H82O18
Mol Weight: 947.166
Botanical Source: Panax ginseng (ginseng) and Panax japonicus (Japanese ginseng)
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ginsenoside Re, a main phytosterol of Panax ginseng, inhibits Ca(2+) accumulation in mitochondria during cardiac ischemia/reperfusion, which is attributable to nitric oxide (NO)-induced Ca(2+) channel inhibition and K(+) channel activation in cardiac myocytes, acts as a specific agonist for the nongenomic pathway of sex steroid receptors, and NO released from activated eNOS underlies cardiac K(+) channel activation and protection against ischemia-reperfusion injury, G-Re also exerts antiischemic effect and induces angiogenic regeneration.[1,2]
Ginsenoside Re has anti-diabetic and anti-hyperlipidemic activities ,can improve hyperglycemia and hyperlipidemia through activation of AMPK, and confer beneficial effects on type 2 diabetic patients with insulin resistance and dyslipidemia. [3]
Ginsenoside Re can improve the cognition of streptozotocin-induced diabetic rats,the mechanism is by its anti-inflammation and antioxidation; glycemic control benefits the attenuation of diabetes-associated cognitive decline.[4]
Ginsenoside Re can hyperpolarize HCAECs,and this effect can be reversed by apamin, suggests ginsenoside Re increases HCAEC outward current via SKCa channel activation, and NSC channel is not involved.[5]
Ginsenoside Re increases the proliferation of CD4 + T cells with decreases cell death, and enhances viability of CD4 + T cells through the regulation of IFN-γ-dependent autophagy activity.[6]
Ginsenoside Re exhibits potent neuroprotective effects against neuroinflammation in a murine model of ALS, ginsenoside Re treatment can reduce the loss of motor neurons and active-microglia-related expression of Iba-1 in the spinal cord of symptom.
References:
[1] Furukawa T, Bai C X, Kaihara A, et al. Mol Pharmacol, 2006, 70(6):1916-24.
[2] Peng L, Sun S, Xie L H, et al. Cardiovasc Ther , 2012, 30(4):e183–e188.
[3] Quan H Y, Yuan H D, Jung M S, et al. Int J of Mol Med, 2012, 29(1):73-80.
[4] Liu Y W, Zhu X, Li W, et al. Pharmacol Biochem, 2012, 101(1):93-98.
[5] Sukrittanon S, Watanapa W B, Ruamyod K. Life Sci, 2014, 115(1–2):15-21.
[6] Son Y M, Kwak C W, Lee Y J, et al. Int Immunopharmaco, 2010, 10(5):626-631.
[7] Cai M, Yang E J. Am J Chinese Med, 2016, 44(2):401-413.
[8] Huang X, Liang T. Chinese Medicine Modern Distance Education of China, 2011, 09(21):131-132.
HPLC of Ginsenoside Re
HNMR of Ginsenoside Re
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
