Product name: 20(R)-Ginsenoside Rg3
Synonym name:
Catalogue No.: BP0040
Cas No.: 38243-03-7
Formula: C42H72O13
Mol Weight: 785.025
Botanical Source: Panax ginseng (ginseng)
Physical Description: White powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
20(R)-Ginsenoside Rg3 has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment, however, 20(R)-Ginsenoside Rg3 has a low bioavailability after oral administration in human, so, 20(R)-Rg3 can be by intranasal administration, the mechanism was related to the increase of the storage of hepatic glycogen, and the decrease of the accumulation of metabolite such as lactic acid and serum urea nitrogen.[1]
20(R)-Ginsenoside Rg3 shows significant effect on the differential expression of cell signaling genes and other related genes in human lung cell line A549.[2]
20(R)-Ginsenoside Rg3 and PEG-PLGA-Rg3 nanoparticles can supress the tumor angiogenesis in vivo,which is perhaps related to the inhibition of expression in MMP-9,HIF-1α,VEGF,IL-1,IL-6 and TNF-α.The PEG-PLGA nanoparticles could improve Rg3's ability on inhibiting the tumor angiogenesis in vivo.[3]
20(R)-Ginsenoside Rg3 has anticarcinogenic effects on Induced Hepatocellular Carcinoma in Rats.[4]
20(R)-Ginsenoside Rg3 elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells, is attributed to its decreasing the enzymatic activity of MMP-2.[5]
20(R)-Ginsenoside Rg3 can restrain A549/DDP cell invasion and metastasis,and it may have relationship with the upregulation of nm23;Rg3 can enhance the A549/DDP cell chemosensitivity to cisplatin,and it may have relationship with the upregulation of caspase-3 and the cell membrane lipid fluidity decreased.[6]
References:
[1] Tang W, Zhang Y, Gao J, et al. Biol Pharm Bull, 2008, 31(11):2024-7.
[2] Chen M W, Yang L, Lei N I, et al. Chinese Journal of Tuberculosis and Respiratory Diseases, 2005, 28(1):37-40.
[3] Geng L, Xing S L, Jing Y U, et al. China Journal of Traditional Chinese Medicine & Pharmacy, 2014(02):601-4.
[4] Xiao L I, Guan Y S, Zhou X P, et al. Journal of Sichuan University. Medical science edition, 2005, 36(2):217-20.
[5] Liu Y, Liu X, Shi L, et al. Clinical Journal of Medical Officers, 2014, 42(11):4-7.
[6] Wang Y, Liu J L, Liu L, et al. Chinese Journal of Health Laboratory Technology, 2011(03):609-11.
[7] Tang M H, Jiang Z H, Zhao Z Z, et al. Chinese herbal medicine, 2004, 35 (03): 280-2.
HPLC of 20(R)-Ginsenoside Rg3
HNMRof 20(R)-Ginsenoside Rg3
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
