Product name: Ganoderol B
Synonym name:
Catalogue No.: BP3162
Cas No.: 104700-96-1
Formula: C30H48O2
Mol Weight: 440.712
Botanical Source:
Physical Description: Powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Ganoderol B with 5α-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats, suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.[1]
Ganoderol B, isolated from the fruiting body of Ganoderma lucidum, is a potent α-glucosidase inhibitor, and α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates, suggests that ganoderol B could be a diabetes mellitus type 2 drug.[2]
Ganoderol B inhibits LNCaP cell expressed androgen receptor (AR), the inhibitory activity caused by its anti-androgen effect.[3]
References:
[1] Liu J, Shimizu K, Konishi F, et al. Bioorgan Med Chem, 2007, 15(14):4966-72.
[2] Fatmawati S, Shimizu K, Kondo R. Phytomed Int J Phytother Phytopharmacol, 2011, 18(12):1053-5.
[3] Zhang J, Zhang H, Jia W, et al. Chinese fungi Society 2015 Annual Conference Abstract Book. 2015.
[4] Zhao J, Zhang X, Li S, et al. J Sep Sci, 2006, 29(17):2609-15.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
