Product name: Wogonin
Synonym name: Vogonin
Catalogue No.: BP1453
Cas No.: 632-85-9
Formula: C16H12O5
Mol Weight: 284.267
Botanical Source: roots of Scutellaria baicalensis and from other plants
Physical Description: Yellow powder
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Wogonin is one major constituent of Scutellaria baicalensis, possesses potent anticancer activities , the activities are largely due to their abilities to scavenge oxidative radicals, to attenuate NF-kappaB activity, to inhibit several genes important for regulation of the cell cycle, to suppress COX-2 gene expression and to prevent viral infections. [1]
Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and.endonuclease, induction of bax protein and suppression of Mcl-1 protein were detected in the process.[2]
Wogonin, baicalin, and baicalein are three major components of Scutellaria, they have anti-inflammatory activity against carrageenan-induced paw edema in rats, the baicalin exhibits the greatest inhibition activity.[3]
Wogonin can suppress the VEGF-stimulated migration and tube formation of human umbilical vein endothelial cells (HUVECs), also restrain VEGF-induced tyrosine phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), strongly suggests that wogonin might be a promising antitumor drug.[4]
Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho-Akt and overexpressing Bax.[5]
References:
[1] Min L W. New therapeutic aspects of flavones: Cancer Treatment Reviews, 2009, 35(35):57-68.
[2] Lee W R, Shen S C, Lin H Y, et al. Biochem Pharmacol, 2002, 63(2):225-36.
[3] Chun-ChingLin, Den-EnShieh. Am J Chinese Med, 1996, 24(1):31-6.
[4] Na L, Ying G, Yun L, et al. Life Sci, 2008, 82(17-18):956-63.
[5] Zhang M, Liu L P, Chen Y, et al. Life Sci, 2013, 92(1):55-62.
[6] Lin D, Liang W. China Pharmacist, 2009, 12(08):1044-6.
HPLC of Wogonin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
