| Catalog No | Package | Original Price | Price | Inventory | Quantity | Operating |
|---|---|---|---|---|---|---|
| BP0337-5mg | 5mg | $420.00 | Sign in |
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Synonym name: Tokoro-base II
Catalogue No.: BP0337
Cas No.: 5066-78-4
Formula: C25H41NO6
Mol Weight: 451.604
Botanical Source: Alkaloid from Aconitum chasmanthum, Aconitum subcuneatum, Aconitum yesoense, Aconitum crassicaule, Aconitum franchetii, Aconitum teipeicum, Aconitum sachalinense var. compactum, Aconitum forrestii, Aconitum pseudogeniculatum and others (Ranunculaceae)
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.
For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
Chasmanine, a diterpenoid alkaloid with significant pharmacological activity, is mainly isolated from the roots of Aconitum crassicaule plants in the Aconitum genus. Aconitum plants have a long history of application in traditional Chinese medicine, widely used for the treatment of diseases such as pain relief, anti-inflammatory, and rheumatism. Zhanhua Aconitum Ning, as a hydrogenated derivative of aconitine alkaloids, has attracted widespread attention in the field of natural product pharmacology in recent years due to its unique chemical structure and multi-target pharmacological activity. This article provides a systematic review of the chemical structure and physicochemical properties, plant sources and extraction methods, pharmacological activity and mechanism of action, pharmacological evaluation, and clinical application prospects of Zhanhuawutongning, aiming to provide theoretical basis and practical guidance for related research.
The chemical formula of Zhanhuawutongning is C25H41NO6, with a molecular weight of 451.6, belonging to the class of diterpenoid alkaloids. Its structural features include diol groups, tertiary and secondary alcohol functional groups, as well as bridged organic heterocyclic systems, and contain tertiary amino groups, exhibiting complex stereochemical configurations. This compound is derived from the hydride of aconitine and has a typical aconitine skeleton, endowing it with strong biological activity.
In terms of physical and chemical properties, the LogP value of Zhanhuawutongning is about 1.77, indicating that it has moderate lipid solubility and is conducive to cell membrane penetration. Its topological polar surface area (TPSA) is 100.99 Å ², with 7 hydrogen bond acceptors, demonstrating strong polarity and hydrogen bond formation ability, which has important implications for its binding to biomolecule targets. Although its blood-brain barrier penetration is not yet clear, its physicochemical properties suggest that it may have some potential for central nervous system activity.
Zhanhua Aconitum mainly comes from plants of the Aconitum genus, especially the roots of Aconitum crassicaule. Aconitum plants are widely distributed in temperate and subarctic regions of Asia, and have abundant alkaloid resources. Traditionally, the roots of these plants have been dried and used in traditional Chinese medicine preparations.
The process of extracting Aconitum carmichaelii usually includes the following steps: first, organic solvents (such as methanol, ethanol, or ethyl acetate) are used to reflux extract the dried plant roots, and the extract is concentrated and then subjected to acid-base adjustment for liquid-liquid distribution to enrich alkaloid components. Subsequently, the crude extract was separated and purified using column chromatography techniques such as silica gel column and C18 reverse phase column. Combined with high-performance liquid chromatography (HPLC) and mass spectrometry (MS) identification, high-purity Zhanhuawuxining was finally obtained. In recent years, the application of ultrasound assisted extraction and microwave-assisted extraction technologies has improved extraction efficiency and purity, reduced solvent usage, and is in line with the concept of green chemistry.
The pharmacological activity research of Zhanhua Aconitum Ning mainly focuses on its analgesic and anti food effects. As a natural diterpenoid alkaloid, it exhibits multi-target regulatory ability, especially showing potential in pain relief related to neurological diseases.
Multiple in vitro and in vivo experiments have shown that Zhanhua Aconitum Ning has significant analgesic effects on various pain models. Its mechanism of action involves multiple neurotransmitter systems and receptor pathways, which can regulate the transmission and perception of pain signals. Compared with traditional opioid analgesics, Zhanhua Aconitum may exert its effects through non opioid receptor pathways, reducing the risk of dependence and resistance.
Zhanhua Aconitum Ning also has significant anti food activity, which can inhibit the feeding behavior of certain insects and pests on plants. This characteristic endows it with potential pesticide development value. Its function may be related to interference with the insect nervous system, and the specific mechanism still needs further research.
In addition to its analgesic and anti food effects, Zhanhua Aconitum Ning may also have anti-inflammatory, antioxidant, and neuroprotective activities. Preliminary in vitro experiments have shown its inhibitory effect on inflammatory mediators, suggesting its potential application in inflammation related diseases.
The pharmacological effects of Zhanhua Aconitum Ning involve multiple molecular targets, especially exhibiting the characteristic of multi-target synergistic regulation in the analgesic mechanism. The main targets include:
The synergistic effect of these multiple targets endows Zhanhuawutongning with a comprehensive analgesic effect, and may reduce the side effects and resistance issues of single target drugs.
The pharmacological evaluation of Zhanhua Aconitum Ning is still in its preliminary stage. Its molecular weight is 451.6, which meets the molecular weight requirements of Lipinski rule. The LogP is 1.77, indicating moderate lipid solubility and facilitating oral absorption. The TPSA is 100.99 Å ², indicating its appropriate polarity, which may affect its bioavailability and distribution.
The number of hydrogen bond receptors is 7, indicating its strong potential to bind to biological targets, but it may also affect the cell membrane penetration ability. There is currently no clear data on safety indicators such as blood-brain barrier penetration, hepatotoxicity, cardiotoxicity, hERG channel inhibition, and mutagenicity (Ames test), which limits the progress of its clinical development.
In terms of pharmacokinetics, there is a lack of systematic in vivo metabolism and excretion research. Based on its structure, it is speculated that Zhanhua Aconitum Ning may be metabolized by the cytochrome P450 enzyme system in the liver, and the metabolites and their activities still need further research. In addition, its half-life, bioavailability, tissue distribution and other parameters in vivo urgently need to be clarified through animal experiments and preclinical trials.
Zhanhua Aconitum Ning, as a natural diterpenoid alkaloid, has broad clinical application potential due to its significant analgesic effect and multi-target mechanism of action. Especially in the treatment of chronic pain, neuropathic pain, and inflammation related pain, Zhanhuawutongning may become a powerful supplement to non opioid analgesics, reducing dependence on traditional analgesics and the risk of side effects.
In addition, its anti food activity provides new ideas for agricultural pest control and has the potential to develop green pesticides. In the future, it is necessary to strengthen the in-depth analysis of its pharmacological mechanism, optimize the extraction and synthesis processes, improve yield and purity, and ensure medicinal safety.
The key to clinical application lies in systematic pharmacokinetic and toxicological studies, establishing safe dosage ranges and dosing regimens. Combining modern drug design techniques such as structural modification and drug carrier systems is expected to enhance its efficacy and safety. Multi center clinical trials will be a necessary step in verifying its clinical efficacy and safety.
Zhanhua Aconitum Ning, as an important diterpenoid alkaloid in Aconitum plants, exhibits a unique chemical structure and multi-target analgesic activity. It has important research value and development potential in the field of natural product pharmacology. Although there is currently incomplete data on its pharmacokinetics and safety, its diverse pharmacological effects and good pharmacokinetic parameters provide a solid foundation for its clinical translation. In the future, through systematic pharmacological and toxicological research and clinical trials, Zhanhuawutongning is expected to become a new generation of safe and effective analgesic drugs and green pesticides, contributing to human health and agricultural production.
