Product name: Formononetin
Synonym name: Formoononetin; Biochanin B; Neochanin; Pratol
Catalogue No.: BP0592
Cas No.: 485-72-3
Formula: C16H12O4
Mol Weight: 268.268
Botanical Source: red and subterranean clovers (Trifolium pratense and Trifolium subterraneum) and of chick peas (Cicer arietinum). the heartwood of Pterocarpus indicus. Found also in Baptisia australis and other plants. Widely distributed in the L
Physical Description: Powder
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Formononetin causes vascular relaxation via endothelium/NO-dependent mechanism and endothelium-independent mechanism which involves the activation of BK(Ca) and K(ATP) channels.[1]
Formononetin-treated Ovx rats has an increased bone osteoprotegerin-to-receptor activator for nuclear κB ligand ratio compared with the Ovx + vehicle group; daily oral administration of formononetin for 12 weeks has a substantial anabolic effect, thus raising the possibility of its use in postmenopausal osteoporosis.[2]
Formononetin exhibits antiviral activities against some members of Picornaviridae, could inhibit EV71-induced COX-2 expression and PGE2 production via MAPKs pathway including ERK, p38 and JNK, thus, formononetin could be a potential lead or supplement for the development of new anti-EV71 agents in the future.[3]
Formononetin reduces hydrogen peroxide (H2O2)-induced apoptosis and improves the levels or activity of indicators of oxidative stress, also inhibits the activation of nuclear factor-kappaB (NF-κB), which is a significant transcription factor for RGC-5 apoptosis.[4]
References:
[1] Wu J H, Li Q, Wu M Y, et al. J Nutr Biochem, 2010, 21(7):613-20.
[2]Tyagi A M, Srivastava K, Singh A K, et al. Menopause, 2012, 19(8):856-63.
[3] Wang H, Zhang D, Miao G, et al. Viro J, 2015, 12(1):1-10.
[4] Jia W C, Liu G, Zhang C D, et al. Eur Rev Med & Pharmaco, 2014, 18(15):2191-7.
[5] Xing J H, Sun X L, Zhou J.Chinese Journal of Pharmaceutical Analysis, 2009(01):73-5.
HPLC of Formononetin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
