Product name: Ganoderic Acid B
Synonym name:
Catalogue No.: BP0616
Cas No.: 81907-61-1
Formula: C30H44O7
Mol Weight: 516.675
Botanical Source: Ganoderma lucidum (reishi)
Physical Description: Powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Oxidization and hydroxylation are the common metabolic pathways for Ganoderic acid B.[1]
Ganoderic acid B has anti-hypertensive triterpene , is an inhibitor of cholesterol biosynthesis.[2]
References:
[1] Guo X, Shen X, Long J, et al. Biomed Chromatogr Bmc, 2013, 27(9):1177–87.
[2] Jones B K. Reishi (Ganoderma): Longevity Herb of the Orient[J].
[3] Wang S Z, Lin D, Lin Z X, et al. Drug Evaluation, 2012, 35 (03): 190-3.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
Ganoderma lucidum（Ganoderma lucidum）As a traditional Chinese medicinal herb, it has always been known as the "fairy grass" due to its rich bioactive ingredients and extensive pharmacological effects. Among them, ganoderic acid B, as an important triterpenoid compound in Ganoderma lucidum, has attracted widespread attention in recent years due to its unique biological activity. Lingzhi acid B not only exhibits various pharmacological activities such as antiviral and immune regulation, but also reveals its regulatory effects on multiple signaling pathways in molecular mechanism research, demonstrating high potential for drug development.
This article systematically reviews the chemical structure and physicochemical properties, plant sources, and extraction methods of ganoderic acid B, with a focus on its pharmacological activity and mechanism of action. Combined with the latest pharmacological evaluation and pharmacokinetic data, it explores its clinical application prospects and future research directions, aiming to provide theoretical basis and research references for natural product pharmacology and new drug development.
Lingzhi acid B (CAS number: 81907-61-1) belongs to the triterpenoid class, with a molecular formula of C30H44O7 and a molecular weight of 516.6750. Its structural characteristics are a typical pentacyclic triterpenoid skeleton, containing multiple hydroxyl and carboxyl functional groups, forming a relatively complex three-dimensional configuration. The LogP value of ganoderic acid B is 3.0056, indicating moderate lipophilicity and low water solubility (0.0226 mg/mL), suggesting limited solubility in vivo and potential impact on its bioavailability. Its topological polar surface area (TPSA) is 128.97 Å ², indicating that it has a certain polarity and is conducive to binding with biomolecules.
The physicochemical properties of ganoderic acid B, such as low blood-brain barrier permeability and no hERG channel inhibition, suggest a lower risk of central nervous system toxicity and cardiac toxicity. The Ames test result is negative, indicating that it does not have significant mutagenicity and meets safety requirements.
Lingzhi acid B mainly comes from fungi of the Lingzhi genus, especially Ganoderma lucidum The content is relatively high in the fruiting body and mycelium. Ganoderma lucidum, as a traditional medicinal fungus, is rich in triterpenoid components, among which ganoderic acid B is a typical representative triterpenoid acid.
The common methods for extracting ganoderic acid B include organic solvent extraction and chromatographic separation. Generally, ethanol or methanol is used for crude extraction, followed by separation and purification through liquid-liquid distribution, silica gel column chromatography, high-performance liquid chromatography (HPLC) and other techniques. In recent years, supercritical CO2 extraction and microwave-assisted extraction techniques have also been used to improve extraction efficiency and purity. The purified ganoderic acid B was structurally identified by nuclear magnetic resonance (NMR), mass spectrometry (MS) and other methods to ensure its purity and structural correctness.
Lingzhi acid B exhibits significant activity in antiviral research. As a telomerase inhibitor, it can inhibit the activation of Epstein Barr virus (EBV) antigen, block virus replication and latency activation process, indicating its potential application value in the prevention and treatment of EBV related diseases such as nasopharyngeal carcinoma and lymphoma. In addition, ganoderic acid B showed a moderate inhibitory effect on HIV-1 protease (IC50 of approximately 170 μ M), indicating its potential as a lead compound for anti HIV drugs, although the inhibitory activity still needs to be optimized.
The research on immune regulation of ganoderic acid B is becoming increasingly abundant, showing its ability to regulate various immune related targets, including Toll like receptor 4 (TLR4), signal transduction and transcription activator 3 (STAT3), interleukin-2 (IL-2), nuclear factor kappa B (NF - κ B), transforming growth factor beta 1 (TGF - β 1), cytotoxic T lymphocyte antigen 4 (CTLA-4), STAT4, IL-10, FOXP3, and interferon - γ (IFN - γ). These targets involve multiple processes such as activation, differentiation, inflammatory response, and immune tolerance of immune cells.
Research has shown that ganoderic acid B can alleviate inflammation, regulate the activity of STAT3 and NF - κ B, and promote immune balance by inhibiting the TLR4 mediated signaling pathway. Its effect on the regulatory T cell (Treg) marker FOXP3 suggests its potential role in regulating the immune microenvironment of autoimmune diseases and tumors.
In addition to antiviral and immunomodulatory effects, ganoderic acid B has also been reported to have anti-tumor activity, including inducing tumor cell apoptosis, inhibiting tumor cell proliferation and migration, etc. The mechanism may be closely related to regulating cell cycle related proteins and inhibiting tumor related signaling pathways such as STAT3 and NF - κ B. In addition, the potential effects of ganoderic acid B in antioxidant, anti-inflammatory, and neuroprotective aspects are gradually being revealed.
The multi-target mechanism of action of ganoderic acid B is the basis of its pharmacological activity. It exerts a wide range of biological effects by directly or indirectly regulating multiple signaling pathways.
Telomerase inhibition and antiviral mechanism
Lingzhi acid B can inhibit telomerase activity, block the activation process of EBV antigen, reduce virus replication and latency activation, and lower the risk of virus related tumors.
HIV-1 protease inhibition
As a moderate inhibitor of HIV-1 protease, ganoderic acid B blocks the maturation of viral proteins and affects the virus lifecycle by binding to the active site of the protease.
Immune regulatory signaling pathway
Treg cell regulation By regulating FOXP3 expression, it affects the quantity and function of regulatory T cells and regulates immune tolerance.
Antitumor mechanism
Lingzhi acid B exerts anti-tumor effects by inducing tumor cell apoptosis, inhibiting proliferation related signaling pathways (such as STAT3, NF - κ B), and blocking immune suppression in the tumor microenvironment.
The pharmacological evaluation of Ganoderma lucidum acid B shows that it has certain potential for drug development. Its molecular weight is moderate, and the LogP value indicates good membrane permeability, but its low water solubility may limit its oral bioavailability. A higher TPSA value indicates stronger polarity, which may affect the ability to penetrate cell membranes.
In terms of safety, ganoderic acid B did not exhibit hERG channel inhibition, reducing the risk of cardiac toxicity. A negative Ames test indicated no significant mutagenicity, meeting the drug safety requirements. Its low blood-brain barrier permeability limits potential side effects in the central nervous system, but may also limit its application in central nervous system diseases.
At present, there is limited pharmacokinetic data on ganoderic acid B. Preliminary studies have shown that its in vivo metabolic stability is good, but further systematic research is needed on its bioavailability and metabolic pathways. In the future, it is necessary to improve its drug performance through structural modification and dosage form optimization.
Lingzhi acid B, as an important representative of Ganoderma triterpenoids, has shown broad application prospects in the fields of antiviral, immune regulation, and anti-tumor due to its multi-target and multifunctional pharmacological properties. Especially in the adjuvant treatment of EBV related diseases and HIV infection, ganoderic acid B has potential clinical value.
The immunomodulatory effect endows it with potential for development in autoimmune diseases, inflammatory diseases, and tumor immunotherapy. Combined with its good safety, ganoderic acid B is expected to become a preferred candidate for natural product drug development.
Future research should focus on the following aspects:
Lingzhi acid B, as a representative triterpenoid natural product in Ganoderma lucidum, has become an important object in the field of natural medicine research due to its unique chemical structure and diverse pharmacological activities. Its potential in antiviral, immune regulation, and anti-tumor aspects provides valuable resources for the development of new natural product drugs. Although there are still some challenges in drug development and pharmacokinetics, with the deepening of research and technological progress, ganoderic acid B is expected to become an important candidate drug for the treatment of various diseases in the future.
In summary, the study of ganoderic acid B not only enriches the theoretical system of natural product pharmacology, but also provides new ideas and directions for innovative drug development, which deserves continuous attention in basic and applied research.
