Product name: Asperosaponin VI
Synonym name: Akebia saponin D
Catalogue No.: BP0207
Cas No.: 39524-08-8
Formula: C47H76O18
Mol Weight: 929.107
Botanical Source: Present in Akebia quinata, Lonicera nigra, Patrinia and Phytolacca spp.
Physical Description: Powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Asperosaponin VI (ASA VI) is a kind of saponin in the medicinal herb Dipsacus asper Wall which has long been used as an antiosteoporosis drug, exhibits a significant induction of proliferation, differentiation and mineralization in MC3T3-E1 and primary osteoblastic cells, it may induce osteoblast maturation and differentiation, and then increase bone formation via increasing BMP-2 synthesis, and activating p38 and ERK1/2.[1]
Asperosaponin VI, a triterpene saponin isolated from Dipsacus asper Wall, plays protective roles on acute myocardial infarction in rats.[2]
Asperosaponin VI has protective effect against hypoxia-induced cardiomyocytes apoptosis probably by activating the PI3K/Akt and CREB pathways.[3]
References:
[1] Yinbo Niu ?, Yuhua Li ?, Huang H, et al. Phytothe Res , 2011, 25(11):1700-6.
[2] Li C, Liu Z J, Li G, et al. Eur J Pharmacol, 2010, 217(Pt 23):4123-31.
[3] Li C, Tian J, Li G, et al. Eur J Pharmacol, 2010, 649(1-3):100-7.
[4] Shan X, Wang J, Wu A. China Pharmacist, 2013, 16(03):388-90.
HPLC of Asperosaponin VI
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
