Product name: Palmatine Chloride
Synonym name: Fibrauretin
Catalogue No.: BP1059
Cas No.: 10605-02-4
Formula: C21H22ClNO4
Mol Weight: 387.86
Botanical Source: Quaternary alkaloid from Jateorhiza palmata (Menispermaceae) and a large number of other spp., mostly in Berberis and Mahonia (Berberidaceae), but spread into many families
Physical Description: White powder
Type of Compound: Alkaloids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Palmatine hydrochloride (PaH), a naturally occurring photosensitizer isolated from traditional Chinese medicine (TCM), can induce remarkable cell apoptosis ,significantly increase intracellular ROS level and significantly kill breast cancer MCF-7 cells; it also has potential in photodynamic therapy on colon adenocarcinoma.[1,2]
Palmatine Hydrochloride has anti-C. albicans effect, the effect is mainly influenced by the growth rate constant (k(2)) and maximum power output P(m)(2) of phase II; it mixes with berberine hydrochloride elicit antifungal activities and could be used to treat M. canis in rabbits. [3,4]
The quenching mechanism of palmatine hydrochloride (PMT)on bovine hemoglobin (BHb) is a static process, the electrostatic force played an important role in the conjugation reaction between BHb and PMT. [5]
Palmatine Hydrochloride treatment can reduce blood sugar and oxidative stress in STZ induced diabetic rats.[6]
References:
[1] Juan Wu, Qicai Xiao, Na Zhang,et al. Photodiagn Photodyn , 2016,7.18.
[2] Wu J, Xiao Q, Zhang N, et al. Photodiagn Photodyn , 2016, 15:53-8.
[3] Kong W, Zhao Y, Wang J, et al. Acta Chim Sin Chinese Edition, 2009, 67(21):2511-6.
[4] Xiao C W, Ji Q A, Wei Q, et al. Bmc Complem Altern M, 2015, 15(1):1-15.
[5] Liu B, Yan X, Cao S, et al. Lumin J Biol Chem Lumin, 2014, 29(3):211-8.
[6] Z Pakseresht, P Norouzi, V Hojati , et al. ZUMS Journal. 2016; 24 (107) :119-29.
[7] Xiang L I, Liu G Y, Jian-Li M A, et al. Pharm J Chinese Peoples Liberation Army, 2013(05):458-60.
HPLC of Palmatine Chloride
HNMR of Palmatine Chloride
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
40.8000
.6061
.6063
.3973
3.1107
24.6646
High
32.3375
2.7512
Yes
No
Yes
No
Yes
Yes
1.8
No
No
No
No
