Product name: Anemoside B4
Synonym name: Pulchinenoside B4; Pulchinenoside C; Chinensioside A
Catalogue No.: BP0170
Cas No.: 129741-57-7
Formula: C59H96O26
Mol Weight: 1221.39
Botanical Source: Anemone chinensis and Root of Pulsatilla chinensis
Physical Description: Powder
Type of Compound: Triterpenoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Anemoside B4(AB4) and tetrandrine(Tet) have some reversal effect on resistant to L-OHP in Lo Vo/L-OHP cells, the molecular mechanism of the resistance reverse effect was related to down-regulation of P-gp for AB4 and down-regulation of z DHHC9 for Tet.[1]
Anemoside B4, anemonin, berberine, jatrorrhizine, palmatine, aesculin, and esculetin are active ingredients of Pulsatillae Decoction , can inhibit the production of IL-6,secretion of IL-8, downregulate E-selectin expression, and decrease the content of TXB(2), they reduce inflammatory response, thus relieving intestinal dysfunction via multiple pathways.[2]
Anemoside B4 might potentially have a capacity to regulate immune responses in vivo via changes in production of these select cytokines by infected endothelial cells.[3]
References:
[1] Min L I, Fang M, Oncology D O. China Oncology, 2015(1):38-44.
[2] Hu Y, Chen X, Duan H, et al. Immunopharm Immunot, 2009, 31(4):550-5.
[3] Hu Y, He K, Wang X. J Immunotoxicol, 2016, 13(2):141-7.
[4] Yeom H S, Suh J H, Youm J R, et al. Bulletin- Korean Chemical Society, 2010, 31(5):1159-64.
HPLC of Anemoside B4
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
