Product name: (R,S)-Goitrin
Synonym name: Goitrin; Epigoitrin; DL-Goitrin; (±)-Goitrin; 5-Ethenyl-2-oxazolidinethione; 5-Vinyloxazolidone-2-thione
Catalogue No.: BP0543-1
Cas No.: 13190-34-6
Formula: C5H7NOS
Mol Weight: 129.177
Botanical Source: Isatis indigotica
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.
For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.
Description:
Epigoitrin and fructopyrano-(1→4)-glucopyranose(FG) from the traditional Chinese medicine Isatidis radix, exhibit in vitro cooperation, they have in vitro anti-virus activity.
References:
Chinese Journal of New Drugs, 2013(9).
The in vitro anti-virus effects and dose-effect relationship of epigoitrin and fructopyrano-(1→4)-glucopyranose based on
To investigate the in vitro anti-virus effects and dose-effect relationship of Epigoitrin and fructopyrano-(1→4)-glucopyranose(FG) from the traditional Chinese medicine Isatidis radix.
METHODS AND RESULTS:
Inhibitory effect of the target components on influenza virus neuraminidase(NA) was determined by fluorescent enzyme immunoassay.The 50% inhibitory concentration(IC50) was used as an indicator to research the relationship between Epigoitrin and FG by equivalent curve analysis.The effective concentrations of Epigoitrin and FG for in vitro anti-virus activity were determined.In the negative samples,the concentration range of target composition was gradually increased to obtain the key efficacy("incremental").Results: The equivalent point of Epigoitrin and FG samples was located below the equivalent line,and the IC50,mix value was less than IC50,add.For anti-influenza A virus activity of the incremental samples of Epigoitrin and FG,the effective concentrations were as follows: the lowest,optimum,and highest concentrations of Epigoitrin were 82.5,225.0 and 289.7 μg·mL-1;those of FG were 138.2,450.0 and 618.9 μg·mL-1.
CONCLUSIONS:
The equivalent curve analysis shows that Epigoitrin and FG exhibit cooperation.We have,for the first time,revealed the effective concentration range for in vitro anti-virus activity of Epigoitrin and FG from Isatidis radix.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
