Product name: Kajiichigoside F1
Synonym name: Euscaphic acid glucoside；Euscaphic acid glucosyl ester;
Catalogue No.: BP3634
Cas No.: 95298-47-8
Formula: C36H58O10
Mol Weight: 650.85
Botanical Source:
Physical Description:
Type of Compound:
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.
For Reference Standard and R&D, Not for Human Use Directly.
HPLC of Kajiichigoside F1
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
177.1400
2.8143
2.8143
.0301
.6601
1.0031
Low
74.3367
5.5502
No
No
No
No
No
No
0.0
Yes
No
Yes
Yes
Kajiichigoside F1 is a natural triterpene saponin compound derived from plants, and due to its remarkable biological activity, it has gradually become a hot topic in pharmacological research of natural products. In recent years, with in-depth exploration of the role of natural products in disease prevention and treatment, dosysidin has shown broad application potential due to its excellent antioxidant properties and multi-target regulatory effects. Antioxidant stress is an important pathological basis for various chronic diseases such as cardiovascular diseases, neurodegenerative diseases, tumors, and inflammatory diseases. Rosisidin has become a key research focus by regulating multiple antioxidant-related targets to protect cells from oxidative damage.
This paper will systematically review the chemical structure and physicochemical properties of ispinaside, its plant origin and extraction methods, with a focus on its pharmacological activity and mechanism of action. It analyzes its pharmacokinetic characteristics in combination with druggable parameters, and finally explores its clinical application prospects and future research directions, aiming to provide a theoretical basis and research guidance for the in-depth development of ispinaside.
Rosa pigside (CAS No.: 95298-47-8) has a molecular weight of 650.85 and is a natural product of the triterpene saponin class. Its molecular structure includes a typical pentacyclic triterpene backbone, connecting multiple sugar groups, giving it high polarity and water-soluble characteristics. The LogP value was 2.8143, indicating moderate lipid solubility, which is beneficial for cell membrane penetration and bioavailability. The total polar surface area (TPSA) is 177.14 Ų. A higher TPSA value usually indicates certain limitations in molecular passage through the cell membrane, especially the low permeability of the blood-brain barrier (BBB), which matches its biological distribution characteristics.
Water solubility is 0.0301, indicating limited solubility in water, but its bioavailability can be improved through appropriate formulation techniques. The hERG channel inhibition test was negative, indicating that spiridin carries a lower risk of cardiotoxicity. The Ames mutagenicity test result was 0.0, indicating very low genotoxicity risk and good safety.
In summary, the physicochemical properties of dosysidin indicate that it is a natural product with good bioactivity potential and relatively high safety, but its water solubility and blood-brain barrier permeability are relatively low, requiring optimization in drug design and formulation development.
Rosa roxburghii is mainly found in Rosa roxburghii Tratt, a plant of the Rosaceae family. Rosa roxburghii is a wild fruit tree widely distributed in the mountainous areas of southwest China. Its fruit is rich in various bioactive components, including polysaccharides, flavonoids, and triterpene saponins. As one of its important triterpene saponin components, spina pigment has significant bioactive value.
Common methods for extracting dosirosein include solvent extraction, ultrasound-assisted extraction, and high-performance liquid chromatography (HPLC) separation and purification. Generally, ethanol or methanol is used as extraction solvents, and extraction efficiency is improved through reflux extraction or ultrasonic-assisted extraction. The extract is concentrated, liquid-liquid fractionated, silica gel column chromatography, and reversed-phase HPLC purification, ultimately obtaining high-purity dosyridin. In recent years, microwave-assisted extraction and supercritical fluid extraction technologies have also been applied to the extraction of spinosin, significantly improving extraction efficiency and purity, and better aligning with green environmental protection concepts.
Optimizing the extraction process not only affects the yield and purity of spina pigment, but also directly impacts the quality assurance of subsequent pharmacological activity research and clinical application.
Research on the pharmacological activity of dosysidin mainly focuses on its antioxidant, anti-inflammatory, anti-tumor, and cell protection effects, with its antioxidant effects being particularly significant.
Rosisidin significantly enhances the body's antioxidant defense system through multi-target regulation. It can activate the nuclear factor E2-related factor 2 (NFE2L2/NRF2) signaling pathway, promoting the expression of downstream antioxidant enzymes such as superoxide dismutase (SOD1, SOD2), catalase (CAT), glutathione peroxidase (GPX1), and hemoglobin oxygenase 1 (HMOX1), enhancing cells' ability to clear reactive oxygen species (ROS) and reducing cellular damage caused by oxidative stress.
In addition, dosiridoside can inhibit the activity of matrix metalloproteinases (MMP1, MMP3), reduce extracellular matrix degradation, protect tissue structural stability, and indirectly exert antioxidant and anti-inflammatory effects. Its regulatory effect on tyrosinase (TYR) also suggests its potential applications in melanin synthesis and skin protection.
Rosisidin reduces pro-inflammatory factor expression by inhibiting oxidative stress-mediated inflammatory responses, thereby alleviating tissue inflammatory damage. Both in vitro cell models and animal experiments have shown its inhibitory effects on inflammatory factors such as TNF-α and IL-6, suggesting its potential for application in inflammatory diseases.
Some studies show that dosypidin can exert anti-tumor effects by inducing apoptosis, inhibiting proliferation and migration of tumor cells. Its antioxidant and anti-inflammatory effects may provide fundamental support for its antitumor activity, but the specific mechanisms still require further research.
The mechanism of action of prickoside mainly revolves around its antioxidant and cell-protective functions, involving multiple signaling pathways and key molecular targets.
NFE2L2 (nuclear factor E2-related factor 2) and its encoding NRF2 protein are core regulatory factors of intracellular antioxidant defense. Siridins promote the cytoplasmic translocation of NRF2 to the nucleus, bind to antioxidant response elements (AREs), initiate transcription of antioxidant enzyme genes, enhance the cell's ability to clear ROS, and reduce oxidative damage.
Rosilidin upregulates the expression and activity of antioxidant enzymes such as SOD1, SOD2, CAT, GPX1, and HMOX1, synergistically scavenging superoxide anions, hydrogen peroxide, and other reactive oxygen species, thereby maintaining intracellular redox balance.
MMP1 and MMP3 are the main collagen-degrading enzymes; overactivation leads to tissue structure destruction and worsening inflammation. Rosisidin protects the extracellular matrix by inhibiting MMP1 and MMP3 activities, slowing tissue damage and inflammatory progression.
The regulatory effect of doxalysidin on TYR suggests it may affect melanin synthesis and skin protection mechanisms, offering potential applications for skin antioxidant and whitening purposes.
The druggability parameters of doxabilin indicate that it has certain potential for drug development, but there are also challenges.
With a molecular weight of 650.85, it is a medium-to-large molecule, with a LogP of 2.81, indicating moderate lipid solubility and facilitating cell membrane penetration. A high TPSA (177.14 Ų) suggests strong polarity, which may affect oral absorption and brain tissue distribution. Water solubility is relatively low (0.0301), requiring formulation technology to improve solubility.
The hERG channel inhibition test was negative, indicating a low risk of heartotoxicity in the dosyridin. Ames test results were 0, indicating no mutagenicity and good safety.
Currently, there is limited pharmacokinetic research on spiricin, but its low blood-brain barrier permeability suggests its application in treating central nervous system diseases is limited. In the future, systematic ADME (Absorption, Distribution, Metabolism, Excretion) studies are needed to clarify its in vivo metabolic pathways and bioavailability, providing a basis for clinical development.
With its remarkable antioxidant and anti-inflammatory activities, doxa glycol shows broad application prospects in the prevention and treatment of various diseases.
Oxidative stress is an important pathological mechanism in cardiovascular diseases, diabetes, neurodegenerative diseases, tumors, and various other chronic diseases. Rosisidin enhances the body's antioxidant capacity by activating the NRF2 signaling pathway, making it a promising natural drug candidate for preventing and treating these diseases.
The regulatory effect and antioxidant properties of dosyrosidase in the field of peroxysolidin give it potential application value in skin anti-aging, whitening, and sun protection. It can be developed into functional skincare ingredients.
Its anti-inflammatory effects offer new approaches for treating inflammatory diseases, and in the future, combined with modern drug formulation technologies, it is possible to develop therapeutic formulations for specific inflammatory conditions.
As a natural triterpenoid saponin with multi-target antioxidant activity, spiniside demonstrates significant cellular protective and anti-inflammatory potential due to its ability to activate the NRF2 signaling pathway, regulate the antioxidant enzyme system, and inhibit matrix metalloproteinases. Its favorable safety and druggability parameters lay the foundation for further drug development. In the future, through systematic pharmacokinetic studies and preclinical validation, combined with innovations in modern formulation technology, dosysidine is expected to become an effective natural drug for preventing and treating oxidative stress-related diseases, providing new directions and opportunities for pharmacological research and clinical application of natural products.
