Product name: Jaceosidin
Synonym name:
Catalogue No.: BP0806
Cas No.: 18085-97-7
Formula: C17H14O7
Mol Weight: 330.292
Botanical Source: Centaurea arguta, Digitalis lanata, Artemisia arctica, Liatris chapmanii, Liatris gracilis, Helichrysum viscosum and others
Physical Description: Yellow powder
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Jaceosidin and Eupatilin are bioactive flavones found in the medicinal herbs of the genus Artemisia, exhibit various antioxidant, antiinflammatory, antiallergic, and antitumor activities, jaceosidin is a competitive inhibitor of CYP1A2 with a K(i) value of 3.8 microM and a mixed-type inhibitor of CYP2C9 with K(i) value of 6.4 microM in human liver microsomes.[1]
Jaceosidin has anti-inflammatory effect, may reduce inflammation by inhibiting NF-kappaB activation.[2]
Jaceosidin has anticancer effect and antiproliferation effect , may be contributed by an induction of apoptosis involving cytochrome c release from mitochondria to cytosol, induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species.[3,4]
Jaceosidin exerts growth inhibitory effect by arresting the cells at G2/M phase and induction of apoptosis.[5]
References:
[1] Ji H Y, Kim S Y, Kim D K, et al. Molecules, 2010, 15(9):6466-75.
[2] Min S W, Kim NJBaek N I. J Ethnopharmacol, 2009, 125(3):497-500.
[3] Min‐Jung K, Do‐Hee K, Won L K, et al. Ann N Y Acad Sci, 2007, 1095(1):483-95.
[4] Lv W, Sheng X, Chen T, et al. J Biomed Biotechnol, 2008(1):394802.
[5] Khan M, Yu B, Rasul A, et al. Evid-based Compl Al, 2011, 2012(1):72-79.
[6] Zhou Q, Sun L L, Jiang B, et al. China Pharmacy, 2013, 24(47):4464-6.
HPLC of Jaceosidin
NMR of Jaceosidin
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
