Synonym name:
Catalogue No.: BP0726
Cas No.: 140369-76-2
Formula: C27H30O8
Mol Weight: 482.529
Botanical Source: the stems of Kadsura heteroclita
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.
For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.
HPLC of Heteroclitin D
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
Heteroclitin D (CAS number: 140369-76-2) is a natural lignin compound derived from medicinal plants of the Kadsura genus. In recent years, with the increasing importance of natural products in drug development, the unique chemical structure and significant biological activity of schisandrin, especially its potential in anti lipid peroxidation and calcium channel regulation, have gradually become a hot topic in pharmacological research. As a malignant tumor with high incidence rate and mortality worldwide, liver cancer urgently needs to develop new effective and low toxic therapeutic drugs. Heterozygous schisandrin exhibits excellent anti-tumor activity by regulating liver cancer-related signaling pathways through multiple targets, and has high drug development value. This article will provide a systematic review of the chemical properties, plant sources, pharmacological activities, mechanisms of action, pharmacological evaluation, and potential applications of alloschisandrin in the treatment of liver cancer, aiming to provide comprehensive reference materials for researchers in related fields.
Heterogeneous Schisandra chinensis extract belongs to the lignin class of natural products, with a molecular formula of C27H30O9 and a molecular weight of 482.5290. Its chemical structure is characterized by a typical lignin skeleton, containing multiple phenolic hydroxyl and methoxy substituents, endowing it with strong antioxidant capacity. The LogP value of this compound is 3.5320, indicating moderate lipid solubility that facilitates membrane penetration. The topological polar surface area (TPSA) is 89.5200, indicating that its polarity is moderate and may affect its absorption and distribution characteristics. Low water solubility (0.0095 mg/mL) suggests that it may enhance bioavailability in vivo in the form of liposomes or other carriers. Heterozygous schisandrin has a high blood-brain barrier penetration ability, indicating that it may also have potential effects on central nervous system diseases. Importantly, the compound does not inhibit hERG channels and the Ames mutagenicity test result is 0.0, indicating its high safety and low toxicity risk.
Heteroschisandrin mainly exists in plants of the Kadsura genus, especially in traditional Chinese medicinal herbs such as Kadsura heteroclita. Kadsura plants are widely distributed in southern China and Southeast Asia, and have always been used to treat rheumatism, liver disease, and inflammatory diseases. The extraction of schisandrin is usually carried out using organic solvent extraction method, with methanol, ethanol or ethyl acetate commonly used as extractants. The extraction process includes plant drying and crushing, extraction, filtrate concentration, and multi-step chromatographic separation and purification. High performance liquid chromatography (HPLC) and mass spectrometry (LC-MS) are widely used for qualitative and quantitative analysis of schisandrin. In recent years, the application of ultrasound assisted extraction and microwave-assisted extraction technologies has significantly improved extraction efficiency and purity, laying the foundation for large-scale preparation.
The pharmacological activity research of heterodyne schisandrin mainly focuses on its antioxidant, anti-tumor, and calcium channel regulating effects. Firstly, its significant anti lipid peroxidation ability protects the integrity of cell membrane structure and reduces oxidative stress damage by clearing free radicals and inhibiting lipid peroxidation chain reactions. In vitro experiments have shown that heterologous Schisandra chinensis extract can effectively reduce the levels of lipid peroxidation products such as malondialdehyde (MDA) and enhance the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD).
Secondly, the heterologous Schisandra chinensis extract inhibits L-type calcium channels, regulates intracellular calcium homeostasis, and affects various cellular signal transduction processes. Calcium signaling plays a crucial role in cell proliferation, apoptosis, and migration, and its regulatory effect provides a potential anti-tumor mechanism basis for the production of alloschisandrin.
In the liver cancer model, heterodyne schisandrin exhibits multiple effects of inhibiting tumor cell proliferation, inducing apoptosis, and inhibiting metastasis. Both in vitro cell experiments and in vivo animal models have confirmed its significant growth inhibitory effect on liver cancer cell lines, with low toxicity and side effects.
The mechanism of action of heterodyne schisandrin involves multiple signaling pathways and molecular targets, particularly in the field of liver cancer treatment. Research has shown that this compound can regulate the following key targets:
These multi-target mechanisms of action enable the potential synergistic effect of heterologous Schisandrin in the treatment of liver cancer, overcoming the resistance problem of single target drugs.
From the perspective of medicinal properties, the atypical Schisandra chinensis extract exhibits excellent medicinal properties. Its moderate molecular weight and lipid solubility are beneficial for oral absorption and cell membrane penetration. The high blood-brain barrier permeability suggests that it may be extended to the treatment of neurological diseases. The low water solubility is a challenge in the development of its formulations, and its bioavailability needs to be improved through techniques such as nanocarriers, liposomes, or solid dispersions.
In terms of safety, the atypical Schisandra chinensis extract does not inhibit hERG potassium channels, reducing the risk of cardiac toxicity. A negative Ames test indicates no significant mutagenicity and meets the safety standards for clinical development.
Pharmacokinetic studies have shown that alloschisandrin is widely distributed and metabolically stable in the body, mainly metabolized through the liver enzyme system, with a moderate half-life. Its clearance rate and bioavailability need to be further optimized to meet clinical medication needs.
Heterozygous schisandrin, as a natural lignin with multi-target regulation, has shown great potential in the treatment of liver cancer. Its antioxidant and calcium channel regulatory functions provide effective intervention methods for apoptosis and proliferation of liver cancer cells. In the future, combining modern drug design technologies such as structural modification and drug carrier systems is expected to enhance its efficacy and bioavailability.
In addition, the high blood-brain barrier permeability of atypical Schisandrin suggests its potential application value in neurodegenerative diseases, brain tumors, and other fields. In combination chemotherapy or targeted therapy, alloschisandrin may exert a synergistic effect, reducing drug resistance and side effects.
However, current preclinical and clinical research on it is still relatively limited, and systematic studies on pharmacokinetics, toxicology, and clinical trials need to be strengthened to verify its safety and efficacy. Future research should focus on dosage form optimization, deepening mechanism of action, and multi center clinical evaluation to promote its translation into clinical applications.
As an important natural lignin product in Kadsura plants, the unique chemical structure and multi-target pharmacological activity of schisandrin have shown broad application prospects, especially in the field of anti liver cancer. Its anti lipid peroxidation effect and L-type calcium channel inhibition function provide new strategies for the growth control of liver cancer cells. The drug efficacy evaluation shows that it has good safety and drug properties, but its water solubility and bioavailability still need to be optimized. In the future, through in-depth mechanistic research and preclinical evaluation, heterodyne schisandrin is expected to become an important candidate molecule in the development of natural product drugs, bringing new hope for the treatment of liver cancer and related diseases.
