Product name: Kaempferol
Synonym name:
Catalogue No.: BP0820
Cas No.: 520-18-3
Formula: C15H10O6
Mol Weight: 286.239
Botanical Source: Very widespread in the plant world, e.g. in Cruciferae, Apocynaceae, Dilleniaceae, Ranunculaceae, Leguminosae, etc.
Physical Description: Yellow powder
Type of Compound: Flavonoids
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Kaempferol is a polyphenol antioxidant found in fruits and vegetables, has beneficial effects in reducing the risk of chronic diseases, especially cancer, it may help to promote the development of cancer by augmenting the body's antioxidant defence against free radicals,and inhibit cancer cell growth and angiogenesis and induce cancer cell apoptosis.[1]
Kaempferol and quercetin have anti-inflammatory effects by modulating of iNOS, COX-2 and CRP, and involving blockade of NF-κB activation and the resultant up-regulation of the pro-inflammatory genes.[2]
Kaempferol is an autophagic enhancer, has a more general protection in Parkinson's disease, can mediate antiapoptotic and antioxidant effects is the enhancement of mitochondrial turnover by autophagy.[3]
Kaempferol and quercetin at concentrations ranging from 0.1 to 100 microM reduce bone resorption in a time and dose-dependent manner, have significant inhibitory effects at concentrations as low as 0.1 microM especially with kaempferol, they exert a potent inhibitory effect on in vitro bone resorption.[4]
References:
[1] Chen A Y, Chen Y C.Food Chem, 2013, 138(4):2099-107.
[2] García-Mediavilla V, Crespo I, Collado P S, et al. Eur J Pharmacol, 2007, 557(2–3):221-9.
[3] Filomeni G, Graziani I, Zio D D, et al. Neurobiol Aging, 2012, 33(4):767-85.
[4] Wattel A, Kamel S, Mentaverri R, et al. Biochem Pharmacol, 2003, 65(1):35-42.
[5] Yuanqing F U, Fengwei M O, Liao H. Medicinal Plant, 2013(1):42-43, 46.
HPLC of Kaempferol
NMR of Kaempferol
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
