| Catalog No | Package | Original Price | Price | Inventory | Quantity | Operating |
|---|---|---|---|---|---|---|
| BP0296-100mg | 100mg | $20.00 | Sign in |
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Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
Butyl 4-hydroxybenzoate (hereinafter referred to as butyl parabenzoate, CAS number: 94-26-8) is an important organic molecular entity widely found in nature, especially in the secondary metabolites of various plants. As a member of the paraben preservative, it is widely used in food, cosmetics, and pharmaceuticals due to its excellent antibacterial properties and low toxicity. In recent years, with the development of natural product pharmacology, research on the pharmacological activity and molecular mechanisms of butyl paraben has deepened, especially showing potential application value in the prevention and treatment of bacterial infection-related diseases. This paper will systematically review the chemical structure and physicochemical properties of butyl para-hydroxybenzoate, plant origin and extraction methods, pharmacological activity, mechanism of action and molecular targets, druggability evaluation, and pharmacokinetic characteristics, and finally explore its clinical application prospects and future research directions.
Butyl para-hydroxybenzoate has the chemical formula C11H14O3 and a molecular weight of 194.23. Its structure consists of a para-hydroxyl-substituted benzene ring connected to a butyl ester group via ester bonds. The presence of hydroxyl groups in the molecule gives it certain polarity, while the butyl ester group increases hydrophobicity, giving it moderate lipid solubility (LogP about 3.2), which positively affects biofilm permeability.
In terms of physicochemical properties, butyl paraben has a topological pole surface area (TPSA) of 46.53 Ų and a hydrogen bond acceptor count of 3, indicating it has certain hydrophilicity and potential for binding to biomacromolecules. Its molecular structure is stable, easily soluble in organic solvents, and at room temperature it appears as a colorless or pale yellow crystalline solid. According to predictions of blood-brain barrier permeability, it has high penetration capacity, suggesting its potential application in central nervous system diseases.
Butyl paraben is widely found in various plants, especially in the roots, stems, leaves, and fruits of certain medicinal plants. Typical plant sources include plants from the Rosaceae, Solanaceae, and Umbelliferaceae families, which synthesize p-hydroxybenzoate compounds via the phenylalanine metabolic pathway. Its content is greatly affected by plant species, growing environment, harvest time, and processing methods.
Common methods for extracting butyl paraben mainly include solvent extraction, supercritical fluid extraction, and microwave-assisted extraction. Traditional solvent extraction mostly uses ethanol, methanol, or ethyl acetate as solvents, extracted by impregnation or reflux, combined with liquid-liquid separation and column chromatography for purification. Modern extraction technologies such as supercritical CO2 extraction are increasingly being applied due to their high efficiency and environmental friendliness, capable of producing high-purity butyl paraben at lower temperatures and reducing the degradation of heat-sensitive components. In addition, microwave-assisted extraction promotes cell wall rupture through microwave energy, improving extraction efficiency and shortening extraction time.
Pharmacological studies on butyl paraben mainly focus on its antibacterial, anti-inflammatory, and antioxidant properties. Numerous in vitro experiments have shown that this compound has significant inhibitory effects on various Gram-positive and Gram-negative bacteria, especially showing low minimum inhibitory concentrations (MIC) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Its antibacterial mechanism involves multiple pathways, including cell membrane destruction, protein synthesis inhibition, and DNA replication interference.
In addition, butyl paraben also exhibits certain anti-inflammatory activity. By inhibiting the release of inflammatory mediators and regulating immune cell function, it can alleviate inflammatory responses. Relevant in vivo model studies have shown protective effects in reducing local and systemic inflammatory responses caused by bacterial infections.
In terms of antioxidant activity, BNT paraben can scavenge free radicals, reduce cellular damage caused by oxidative stress, and further support its potential in preventing and treating infections and related complications.
The mechanism of action of butyryl paraben against bacterial infections involves multiple molecular targets, mainly including MCL1, TLR4, PTPN1, APEX1, SERPINE1, PRKCA, GYRA, GYPB, FTSZ, and FABI.
In summary, butyl paraben achieves effective inhibition of bacterial infections and immune regulation through multi-target and multi-pathway synergistic effects.
From the perspective of druggability parameters, Butyl paraben has good potential for drug development. Its molecular weight is 194.23, which fits the ideal range of Lipinski's rules. The LogP value is 3.2, indicating moderate lipid solubility, which is beneficial for cell membrane penetration and distribution in vivo. TPSA is 46.53 Ų, with 3 hydrogen bond receptors, both contributing to improved bioavailability.
Toxicological evaluations showed that the acute toxicity of butyl paraben was relatively low, with an LD50 of about 2000 mg/kg, indicating high safety. Hepatotoxicity, cardiotoxicity (including hERG channel inhibition), and genotoxicity (Ames test) were all negative, further supporting its safety.
Pharmacokinetics, this compound demonstrated good blood-brain barrier penetration, suggesting its potential in treating central nervous system diseases. Its metabolism in the body mainly occurs through the hepatic enzyme system, with stable metabolites and no significant toxicity. It has a moderate half-life in the body, which helps maintain effective drug concentrations.
However, further research into its oral bioavailability and metabolic pathways is still needed to optimize administration regimens and formulation design.
Butyl paraben, as a naturally derived compound, has broad clinical application prospects due to its multi-target antibacterial properties and good safety. In the prevention and treatment of bacterial infections, especially those with resistant strains, it may become a novel adjunct or alternative therapy. Moreover, its anti-inflammatory and antioxidant properties offer potential therapeutic strategies for infection-related inflammatory diseases.
Future research should focus on the following aspects:
Butyl paraben, as a natural compound with multiple biological activities, exhibits excellent antibacterial, anti-inflammatory, and safety characteristics. Its multi-target mechanism provides new ideas and strategies for treating bacterial infections. Although there is currently a preliminary understanding of its pharmacological effects and druggability, in-depth mechanistic studies and systematic preclinical evaluation are still needed to advance its clinical application. In the future, with continuous advances in natural product pharmacology and modern drug development technologies, butyl paraben is expected to become an important candidate in the anti-infective field, contributing new strength to human health.
