1、 Pharmacopoeia standard of mulberry parasites
This product is the dried leaves, stems and branches of the parasitic plant taxillus chinensis (dc.) Danser. Harvest and cut from winter to next spring, remove thick stems, cut into sections, dry, or dry after steaming.
; The surface is reddish brown or grayish brown, with fine longitudinal lines, and most of the small protruding Brown lenticels, and some of the tender branches can see brown hairs; It is hard, with irregular section, reddish brown skin and light wood color. Leaves curly, with short stalks; After flattening, the leaves are oval or oval, 3 ～ 8cm long and 2 ～ 5cm wide; the surface is yellowish brown, the young leaves are covered with fine hairs, the apex is blunt, the base is round or wide cuneate, and the whole margin; Leathery. The breath is slight and the taste is astringent.
[identification] (1) cross section of stem: epidermal cells sometimes remain. The cork layer is more than 10 rows of cells, and some contain brown matter. The cortex is narrow, the old stem has stone cell groups, and the parenchyma cells contain brown matter. There are stone cell groups and fiber bundles in the middle column sheath, which are intermittently circular. Phloem is very narrow, with scattered stone cells. The intrafascicular cambium is obvious. ; The ducts are scattered individually or clustered in 2-3. There are stone cell groups in the pulp, and the parenchyma cells contain brown matter. Some stone cells contain calcium oxalate crystals or brown substances.
The powder is yellowish brown. Stone cells are square and round, with occasional branches. Some walls are thick on three sides and thin on one side, containing calcium oxalate crystals. The fibers are in bundles with a diameter of about 17 μ M. Marginal pitted conduit, reticulated conduit and threaded conduit are common. Fragments of stellate hair branches are rare.
(2) Take 5g of this product powder, add 60ml of methanol water (1:l), heat and reflux for 1 hour, filter while hot, concentrate the filtrate to about 20ml, add 10ml of water, add about 0.5ml of dilute sulfuric acid, boil and reflux for 1 hour, shake and extract twice with ethyl acetate, 30ml each time, combine the ethyl acetate solution, concentrate to 1ml as the test solution. In addition, take quercetin reference substance and add ethyl acetate to make a solution containing 0.5mg per 1ml as the reference substance solution. According to the test of thin-layer chromatography (general rule 0502), suck 10 μ l of each of the above two solutions, dot them on the same silica gel G thin-layer plate prepared with 0.5% sodium hydroxide solution, use toluene (water saturated) - ethyl formate formic acid (5:4:1) as the developing agent, develop, take out, dry, spray 5% aluminum trichloride ethanol solution, and view under the ultraviolet light (365nm). In the chromatogram of the test sample, fluorescent spots of the same color appear at the corresponding positions of the chromatogram of the control sample.
[inspection] take 10g of cardiac glycoside crude powder, add 50ml of 80% ethanol, heat and reflux for 30 minutes, filter, evaporate the filtrate, heat 10ml of water to dissolve the residue, filter, add diethyl ether to shake and extract the filtrate four times, 15ml each time, discard the diethyl ether layer, take the lower aqueous solution, add lead acetate saturated solution to complete precipitation, filter, add 10ml of ethanol to the filtrate, add sodium sulfate saturated solution to remove lead, filter, add trichloromethane to shake and extract the filtrate three times, 15ml each time, combine the trichloromethane solution, and concentrate to 1ml. Take the concentrated solution and put it on the filter paper. After drying, drop alkaline 3,5-dinitrobenzoic acid solution (take 1ml of Dinitrobenzoic acid test solution and 1ml of sodium hydroxide test solution, mix them), and it shall not show purple red.
Decoction pieces
[processing] remove impurities, wash slightly, moisten thoroughly, cut thick pieces or short sections, and dry. . The outer skin is reddish brown or grayish brown, with fine longitudinal lines, and most of the small protruding Brown lenticels, and some of the tender branches can see brown hairs. The cut skin is reddish brown, and the wood is light in color. The leaves are mostly curly or broken, and the intact ones are oval or oval after flattening, with a yellowish brown surface. The young leaves are covered with fine hairs, with a blunt apex, a round base or a wide wedge, and are entire; Leathery. The breath is slight and the taste is astringent.
[identification] [inspection] is the same as that of medicinal materials.
[nature, taste and meridian tropism] bitter, sweet and flat. Return to liver and kidney channels.
[functions and indications] dispel wind dampness, tonify liver and kidney, strengthen muscles and bones, and soothe fetus. .
[usage and dosage] 9 ～ 15g.
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2、 Chemical constituents of parasitic mulberry

Flavonoids in the leaves of Sichuan mulberry parasites:quercetin ，Quercitrin，Avicularin And a small amount of d-catechol.

3、 Pharmacological effects of mulberry parasites

1. diuretic effect
Oxalis corniculata dogs can cause diuretic effect by intravenous injection of Physalis gmelini, 0.5 mg / kg, and the effect is more significant when the dose is increased. . Although its action intensity is less than aminophylline, its toxicity is only 1/4 of aminophylline, so its treatment width is relatively large.

2. Depressurization
The hypotensive effect of Physalis gmelini on anesthetized dogs lasted for a short time and was prone to rapid tolerance. According to preliminary tests, on isolated guinea pig heart specimens with normal beats and fibrillations, sangsheng (granule) has the effect of relaxing coronary vessels, and can antagonize pituitrin, while it first inhibits and then increases myocardial contractility.

3. antiviral effect
Sangsheng decoction has a significant inhibitory effect on poliovirus and other enteroviruses in vitro (monkey kidney monolayer epithelial cell tissue culture). Poliovirus is inhibited within one hour of direct contact with the drug, which may be a direct inactivation effect.