Mugwort leaf
1、 Pharmacopoeia standard of Folium Artemisiae argyi       This product is the dried leaves of Artemisia argyi levl. et vant., a Compositae plant. In summer, the flowers are picked before they bloom, removed impurities, and dried in the sun.
      [properties] this product is often wrinkled, broken and has a short handle. After flattening, the intact leaves are oval, pinnately cleft, and the lobes are oval lanceolate, with irregular coarse serrations at the edges; The upper surface is grayish green or dark yellowish green, with sparse pubescence and glandular dots; The lower surface is densely covered with gray white fluff. It is soft. It smells fresh and tastes bitter.
      [identification] (1) the powder of this product is green brown. There are two kinds of non glandular hairs: one is T-shaped hair, the apical cells are long and curved, the two arms are unequal in length, and the stalk has 2-4 cells; The other is uniseriate non glandular hair, with 3-5 cells. The apical cells are long and twisted, often broken. The surface of glandular hair is shaped like a sole, which is formed by the relative superposition of 4 and 6 cells, and has no handle. Calcium oxalate cluster crystals, 3-7 μ m in diameter, exist in mesophyll cells.
      (2) . Another 1g of Artemisia argyi leaf reference medicinal material was prepared into the reference medicinal material solution by the same method. According to the test of thin-layer chromatography (general rule 0502), suck 2-5 μ l of each of the above two solutions, dot them on the same silica gel G thin-layer plate, use petroleum ether (60-90 ℃) - toluene acetone (10:8:0.5) as the developing agent, develop, take out, dry, spray 1% vanillin sulfuric acid solution, heat at 105 ℃ until the spots are clear. In the chromatogram of the test sample, the main spot with the same color appears at the position corresponding to the chromatogram of the control medicinal material.
      [check] moisture   Not more than 15.0% (the fourth method of general rule 0832).
      Total ash   Not more than 12.0% (general rule 2302).
      Acid insoluble ash   Not more than 3.0% (general rule 2302).
      [content determination] determine according to gas chromatography (general rule 0521).
      Chromatographic conditions and system suitability test   Methyl silicone rubber (SE-30) was used as the stationary phase, and the coating concentration was 10%; . The number of theoretical plates shall not be less than 1000 according to the eucalyptus oil peak.
      Preparation of reference solution   Take an appropriate amount of Eucalyptus oleoresin reference substance, weigh it accurately, add n-hexane to make a solution containing 0.15mg per 1ml.
      Preparation of test solution   . Make up the lost weight with n-hexane, shake well, filter, and take the continuous filtrate.
      Assay   Precisely suck 2 μ l of the reference solution and 2 μ l of the test solution respectively, inject them into the gas chromatograph, and determine.
      According to the calculation of dry products, the content of Eucalyptus oleoresin (c10h8o) shall not be less than 0.050%.
      Decoction pieces
      [processing] Wormwood Leaves remove impurities and stems, and screen out dust.
      [character], [identification], [inspection], [content determination] are the same as those of medicinal materials.
      Vinegar wormwood charcoal   Remove the Artemisia argyi leaves, stir fry them according to the charcoal roasting method (general rule 0213) until the surface is scorched black, spray vinegar, and fry them dry.
      For every 100kg of mugwort leaf, 15kg of vinegar was used.
      The product is irregular fragments with dark brown surface and thin strip-shaped petioles. With vinegar aroma.
      [identification] (except for the superfine powder) is the same as that of medicinal materials.
      [nature, taste and meridian tropism] pungent, bitter and warm; There is little poison. It belongs to the liver, spleen and kidney meridians.
      ; External use dispels dampness and stops itching. It is used for hematemesis, bleeding, metrorrhagia and metrorrhagia, menorrhagia, fetal blood leakage, less abdominal cold and pain, irregular menstrual cold, uterine cold infertility; External treatment of skin itching. Artemisia argyi charcoal warming meridian hemostasis, used for asthenic cold bleeding.
      [usage and dosage] 3 ～ 9g. Apply an appropriate amount externally for moxibustion or fumigation.
      [storage] store in a cool and dry place.


2、 Chemical constituents of Folium Artemisiae argyi
1. Artemisia argyi leaves contain 0.45% - 1.00% volatile oil, from which the following were identified: 2-methylbutanol, 2-hexenal, cis-3-hexene-1-ol, tcmlibicyclone, α - thujene, α - pinene,Camphene（camphene）， Sabinene, β - pinene, 1-octen-3-ol, 2,4 (8) - p-montediene [2,4 (8) -pinthadiene], p-cymene,Cineole(1,8-cineole), γ - Terpinene, artemisiaalcohol, α - Terpinene, dimethylstyrene,camphor（camphor），Borneol（borneol）， Isoborneol, 4-terpinen-4-ol, p-cymene - α -ol,α - terpineol（α-ter-pineol）， CIS pieritol, Verbenone, myrtenol, tcmlibans piperitol, tcmlibans carveol, CIS carveol, cis-3-hexenylacetate, p-isopropyl benzaldehyde, carvone, carvone, perilaldehyde, bornylacetate,Perilla Alcohol（perilla-al-cohol），Carvacrol（carvacrol），Eugenol（eugenol）， (Wanggu) (copaene), β -borbonene, β -elemene,Methyl eugenol（methyleugenol）， Tcmlibans caryophyllene, cis- β -farnesene, humulene, β -maalien, tcmlibans- β -farnesene, β -selinene, γ -muurolene, γ -elemene, α -muurolene, nerylpropionate, γ -ξ - ξ -cadinene, caryophylleneoxide, ledol, There are 60 components including pentadecanal, hexahydroarnesylacetone, dibutylphthalate, palmitic acid, etc. [1]. It is also reported that 34 components are reproduced from the volatile oil of wild mugwort leaves produced in Laoshan, Shandong Province, of which the content is relatively high: limonene, sabinene, α - and β - pinene, borneol acetate, CIS - β - farnesene, α - phellan drene..the main components of the volatile oil are as follows:the main components of the volatile oil are limonene, sabinene, α - and β - pinene, α - farnesyl acetate, cis - β - farnesene, α - phellandrene, α - farnesene, α - farnesene, α - farnesyl acetate, α - farnesene, α - Farnese, α - farnesene, Citcmlibonellol, oct-7-en-4-ol, methylisopropylbenzene,Cineole, camphenehydrate, 1,4-cineole,camphor，Borneol, 4-terpineol, α - terpineol, trans geraniol, puerarin, Perillaldehyde, borneol acetate,Eugenol， , There are 32 components such as Dihydroactinidiolide, widdrene, vinyl2,2-dimethyl-3-henyl-propi-onate [3]. , 8 β - lactone [1-oxo-4 α -acetoxyeudesam-2,11 (13) -dien-12-8 β -olide][5]; Triterpenoids: α - and β - amyrins, friedelin [5], α - and β - amynacetate, lupenone, muctinone, fernenone, 24 methylenecyclo bromelanone, simiarenol, 3 β - tetraxy-9 β, 19 cyclo-23 (E) ene-25, 26 diol [3 β -methoxy-9 β, 19-cycolanost-23-25,26-diol]; Other ingredients:β - sitosterol（β-sitosterol），Stigmasterol（stigmasterol）[5]， Ethyl palmitate, ethyl oleate, ethyl linoleate, trans phenylmethylsuccinic acid [8] and nickel, cobalt, aluminum, chromium, selenium, copper, zinc, iron, manganese, calcium, magnesium and other elements [9].

3、 Pharmacological effects of Folium Artemisiae argyi
1. antibacterial effect:
1.1. Folium Artemisiae argyi has antibacterial effect on 10 gram positive aerophilic bacteria in vitro, including Bacillus anthracis, α - hemolytic streptococcus, B-hemolytic Streptococcus, diphtheria bacilli, pseudodiphtheria bacilli, pneumococcus, Staphylococcus aureus, Staphylococcus citri, Staphylococcus albicans, Bacillus subtilis, etc
1.2. fumigation with mugwort Ono also has bacteriostatic effect on a variety of pathogenic fungi.
1.3. the water decoction of wild wormwood can inhibit Staphylococcus aureus, α - hemolytic streptococcus, Diplococcus pneumoniae, diphtheria bacilli, Shigella sonnei, typhoid and paratyphoid bacilli, Vibrio cholerae, etc. to varying degrees in the test tube.
2. antifungal effect
3. antiasthmatic effect:
3.1. moxa leaf oil can directly relax the smooth muscle of guinea pig trachea, and can also resist the phenomenon of tracheal contraction caused by acetylcholine, barium chloride and histamine; And increase lung perfusion volume in guinea pigs.
3.2. wormwood infusion has a relaxing effect on the bronchus of guinea pigs.
4. choleretic effect
5. inhibition of platelet aggregation
6. hemostatic effect
7. effect on gastrointestinal tract and uterus
8. effect on cardiovascular system
9. anti allergic effect