In the early 1980s,OlaquindoxAs a feed additive, it has been popularized and used in China. It is a kind of feed additive with low toxicity, high efficiency, low dosage, antibacterial and growth promoting, which has been produced and used in China in recent years. It can promote protein synthesis and enhance metabolism of the body, so as to improve the utilization rate of protein in feed, especially for Gram-negative bacteria. At present, the drug has been widely used in livestock and poultry breeding, but the toxicity of the drug varies greatly with animal species. Especially for birds and fish, it has moderate to obvious cumulative toxicity and certain genetic toxicity. As a growth promoter, olaquindox is forbidden to be used in birds, fish and other animals.

（1） Cause  

The toxicity of olaquindox to animals is the most sensitive to birds, which can be divided into acute poisoning, cumulative poisoning and chronic poisoning. It often causes changes in animal appearance and organs, and causes pathological changes in blood, liver, kidney and other tissues. It can seriously damage the liver and kidney of animals and cause changes in physiological and biochemical indicators. At the same time, olaquindox can cause early embryonic death of animals, inhibit the hematopoietic function of bone marrow, and lead to anemia.

（2） Clinical symptoms  

In the acute cases, the ducks were extremely depressed, shrinking their heads, standing still, moving slowly, salivating, diarrhea, waste food and death. Some of them trembled, fell to the ground and kicked their legs, and fell back to death. A few geese are depressed, eat little or no food, have soft feet, drooping wings, bow their heads and are unwilling to walk. General disease course: the ducks are depressed, with loose feathers and necks, drooping wings, poor appetite, increased appetite for drinking, and salivation in the mouth; Walking and rocking, head twitching, foot paralysis, dyspnea, and finally exhaustion and death. The ducks with a slightly longer course of disease are emaciated, with blisters on the upper beak, breaking and peeling, drying and cracking, the beak is short at the top and long at the bottom, and some ducks only have unilateral or bilateral blindness.

（3） Emergency treatment

1. treatment: stop feeding olaquindox premix immediately. Add 0.1% ~ 0.15% sodium bicarbonate, 6% ~ 8% white sugar or 5% glucose alternately to the drinking water, or feed 5 ~ 10 times the nutritional requirement of the compound vitamin at the same time. In order to promote the excretion of unabsorbed drugs in the digestive tract, 5% sodium sulfate solution was used for drinking the seriously ill ducks.  

2. prevention: because chickens and ducks are sensitive to this product, it is stipulated in the maximum residue limit of animal food and veterinary drugs, the code of veterinary drugs of the people's Republic of China (2000) and the scope of use of feed drug additives issued by the Ministry of agriculture that olaquindox is prohibited for birds and can only be used for pigs with a weight of no more than 35 kg. When using olaquindox for disease treatment, the dosage should be accurately calculated. The mixture must be evenly mixed in the feed, and it cannot be used in excess of the dosage or course of treatment.