Sophoridine base(sophoridine,   SR) is a monomer alkaloid extracted and isolated from sophoraalopecuroidesl, a Sophora plant in the pea family. Its synonym is sophoridine. It is found that sophoridine has many pharmacological effects. Sophoridine has a significant effect on malignant trophoblastic tumor, malignant lymphoma and digestive tract tumor. It is a kind of high-efficiency and low toxicity anticancer alkaloid and a national class of new anticancer drugs.

    At present, the in vivo tumor inhibition test has confirmed that sophoridine has an effect on mouse sarcoma S180,   S180A，S37， Ehrlich ascites carcinoma (ECA), cervical carcinoma 14 (U14), Lewis lung cancer and other animal transplanted tumors have inhibitory effects, and the inhibition rate is 30% ~ 60%. In particular, it has a significant inhibitory effect on mouse sarcoma S180, and has no significant effect on the immune function of mice. Sophoridine has anti-tumor effects, and its mechanisms are as follows: ① direct killing effect on tumor cells; ② Inhibition of tumor cell proliferation; ③ Inducing tumor apoptosis; ④ Inducing differentiation of tumor cells; ⑤ Inhibition of tumor metastasis; ⑥ Reverse the drug resistance of tumor cells.

    Sophoridine has many pharmacological activities and has important clinical value. The significant anti-tumor effect has become a hot spot in the field of tumor research. Traditional Chinese medicine has the advantage of producing comprehensive effects on multiple targets, organs and systems. The discovery and application of antineoplastic effect of sophoridine have brought good news to cancer patients. At the same time, sophoridine has significant effects on anti-virus, anti-inflammatory, immunosuppression, anti arrhythmia and so on. With the progress of science and technology and the further deepening of related research, there have been reports of oxysophoridine, Sophoridine Hydrochloride, sophoridine mixed with other sophoridine to adjust the dose for the treatment of cancer and other diseases. All these laid a solid foundation for the development and application of sophoridine. It is believed that in the near future, human beings will have more and more in-depth understanding and extensive application of sophoridine, a new anti-cancer star.