Indigo naturalis is a dicotyledonous medicinal plant, Malan , dicotyledonous plant medicine, leguminous plant indigo, dicotyledonous plant medicine, cruciferous plant Isatis indigotica, Herba Isatidis, or Polygonaceae plant Polygonum blueleaf food leaves or stems. Indigo naturalis can fight cancer, which is known by many doctors. This is because indigo naturalis containsIndirubinIndirubin has a good inhibitory effect on transplanted tumors in animals. The therapeutic dose of indirubin can improve the phagocytic function of animal monocyte macrophage system, and indirubin has an effect on dysplastic granulocytes and eosinophils.
Indirubin is an effective component of anti leukemia isolated from indigo naturalis. It is a pair of indole antitumor drugs. It can inhibit a variety of transplanted animal tumors and destroy leukemia cells; Under the action of indirubin, most of the degenerated and necrotic cells showed swelling and soluble necrosis. It was found that indirubin could also enhance the phagocytic capacity of mononuclear macrophage system in animals. Indirubin has no direct effect on protein synthesis, and its inhibition on DNA synthesis is due to the inhibition of DNA polymerase, which affects DNA polymerization. Indirubin is mainly used for chronic myeloid leukemia, with a total effective rate of 87.3%. Its effect of reducing leukocyte is similar to that of malilan, and the effect of reducing liver is better than that of malilan, but the remission effect of hemogram and bone marrow is worse than that of malilan, and there is no cross resistance with malilan. It can be used for myelodysplasia and eosinophilia. Indirubin has no inhibitory effect on human immune function. The excretion of uric acid and β - aminoisobutyric acid in the course of treatment is parallel to the change of leukocytes in peripheral blood, which is also different from the change rule in the course of radiotherapy or chemotherapy with malilan and mercaptopurine.
The clinical effect of indirubin is at least comparable to that of malilan. The toxic and side effects were pain around the umbilicus, mild nausea, increased number of stools, and bloody stools in severe cases, but disappeared after stopping the drug. No abnormal liver, kidney, ECG, etc.