Baihuadan is a national medicinal material in China. It is rich in resources and widely distributed. It has a very obvious effect in the treatment of rheumatic joint pain, blood stasis amenorrhea, traumatic injury, swelling, poison, acne, scabies and other diseases.Plumbago quinoneIt is the main active component of Plumbago alba. It has been found that plumbago Alba quinone has anti-tumor, anti liver fibrosis, antibacterial and anti-bacterial properties; The pharmacological effects of anti-inflammatory and preventing cerebral ischemia have been confirmed by experiments, and have a good development prospect.

    It was found that plumbagine could significantly inhibit the proliferation of human hepatoma cell line HepG2 with the increase of drug concentration (2,8,32,128 μ mol/l) and the prolongation of action time (24,48,72 h). Zhaoyanli et al. Confirmed for the first time that plumbagine can inhibit acute promyelocytic leukemia (APL) cell line   NB4 can proliferate, induce apoptosis and block cell cycle progression.   Liu Chao and other researchers have shown that plumbago quinone has a good inhibitory effect on the growth of human breast cancer cell MDA-MB-231; In addition, it was found that different concentrations of Plumbago quinone inhibited the expression of transforming growth factor - β 1 in human hepatic stellate cells stimulated by leptin (medium and high concentrations of 16.8 μ mol · L - 1  It can inhibit the synthesis of hsc-ecm and play the role of anti liver fibrosis. Liuxuemei et al. Inhibited the proliferation and α - SMA expression of human hepatic stellate cells stimulated by leptin in different concentrations (16 μ mol · L - 1  It can inhibit the synthesis of hsc-ecm and play the role of anti liver fibrosis.

    Some foreign researchers have shown that plumbago quinone can inhibit NF kb in human lung cancer cells; AP－1； E. coli; It can significantly inhibit the dependence of colon cancer cells on COX-2; And it is a new nrf2/are activator, which can prevent cerebral ischemia. However, there is very little research on the toxicity and clinical medication of Plumbago quinone. In the future, it is necessary to carry out further research on toxicity, pharmaceutical preparations and clinical medication. Starting from this deficiency, this paper discusses its broad application and development space of new drugs, which will be the highlight of the application of national new drugs in clinical practice in China.