Ginsenoside Rb1It is one of the representative components of Ginsenosides of Panax ginseng alcohol system. It belongs to dammarane type triterpenoid saponins. It is easily soluble in water, ethanol and methanol. It is mainly distributed in Panax ginseng, Panax notoginseng, American ginseng and other plants of Acanthopanax family. It is their main active component and has a variety of biological activities. It is found that ginsenoside Rb1 can promote the regeneration of injured nerves!

    It is generally believed that neurons cannot regenerate after injury, and ear nerve fibers can regenerate under certain conditions. After peripheral nerve injury, the innervated muscles immediately become paralyzed, muscle cells gradually atrophy, intercellular fibers proliferate, and motor endplates deform and even disappear. Therefore, peripheral nerve injury and regeneration is a big problem in the medical field, and it is also very important. The experiment confirmed that ginsenoside Rb1 can promote the rapid proliferation and differentiation of Schwann cells in vitro, and contribute to the regeneration of injured nerves.

    Spinal cord lateral cord injury is a kind of neurodegenerative disease, which can lead to neuron loss and axonal degeneration, resulting in local disability or complete paralysis. An important treatment strategy for spinal cord lateral cord injury is to improve the survival rate of neurons and promote the regeneration of axons; Ginsenoside Rb1 and Rg1 can protect lateral funiculus neurons from excitotoxicity induced by glutamate and kainic acid, and can also avoid oxidative stress injury caused by hydrogen peroxide. This neuroprotective effect is also dose-dependent, suggesting that RB1 can be developed as an effective drug preparation for the treatment of spinal lateral funiculus injury.

    In conclusion, extensive and in-depth basic research on ginsenoside Rb1 promoting peripheral nerve regeneration will bring hope for the cure of patients with spinal cord injury.