Malignant tumor is a great enemy of human health. In recent years, it has become a new research direction to explore new anticancer drugs for tumor treatment from the treasure house of traditional Chinese medicine.JugloneIt is a naphthoquinone component, which exists in the root bark, bark, green fruit bark and leaves of Juglans mandshurica and Juglans mandshurica in the walnut family. It has a clear anti-tumor effect. In addition, it also has antibacterial, anti-inflammatory and other pharmacological effects. Therefore, it has attracted more and more attention.

    Juglone extracted from Juglans mandshurica has obvious anticancer activity against S180 solid tumor, MOUSE ASCITIC liver cancer and spontaneous gastric cancer. Juglone has obvious anticancer activity against decimal inhibitory breast cancer and makes the mitosis of Ehrlich ascites cancer cells abnormal. Juglone can directly inhibit the proliferation of tumor cells in vitro, and its anti-tumor effect is to kill tumor cells directly. The results showed that juglone could significantly inhibit the DNA synthesis of tumor cells, and the effect increased with the increase of dose. It was observed by electron microscope that juglone mainly affected mitochondrial vacuolation in HEPA cells. Thus, the proliferation of tumor cells is limited due to the lack of energy supply, so as to achieve the anti-tumor effect. Juglone mainly inhibited the S phase of cell growth. The more phenolic hydroxyl groups in the compound, the greater the cytotoxicity. In addition, some experiments have found that juglone can block the potassium channels of human peripheral blood lymphocytes, and the maintenance of the activity of potassium channels is considered to be a prerequisite for cell growth and T cell proliferation. Therefore, it is considered that this effect of juglone, if not the only one, is also an important way for juglone to induce apoptosis. In addition, juglone can directly modify the sulfhydryl group to break the pre transcriptional complex of RNA, inhibit the synthesis of cell mRNA, and directly block transcription.

    Carry out in-depth clinical and pharmacokinetic research on juglone, and make a more comprehensive exploration on its anti-tumor effect, so as to provide the possibility for tumor patients to play a better role.