With the rapid development of society, the pressure from all aspects is also increasing. The resulting mental diseases are also increasing. Among them, the number of patients with depression is also increasing. Depression is a syndrome characterized by significant and lasting depression. It has become one of the important diseases endangering modern human health. According to the prediction of the World Health Organization, depression will become the second largest disease next to heart disease by 2020. So it is becoming more and more important to find a way to cure depression. At present, the treatment of depression mainly uses chemical drugs, which has the disadvantages of low curative effect and large toxic and side effects. The research and development of anti depressant drugs at home and abroad have gradually paid attention to traditional drugs and natural drugs. It has been found that isoquercetin has certain antioxidant, anti-tumor and anti platelet aggregation effects.

    The biological changes in most patients with depression are due to the activation of hypothalamus pituitary adrenal axis, which has been proved to be caused by excessive secretion of adrenocorticotropic hormone and cortisol. Some studies suggest that isoquercetin scavenging free radicals in vivo is part of the antidepressant mechanism of traditional Chinese medicine. The main mechanisms of action are as follows: 1. Inhibit the multiple activation of hypothalamic pituitary adrenal axis, down regulate the levels of adrenocorticotropic hormone and cortisol in peripheral blood, and affect the content of 5-hydroxytryptamine and dopamine in prefrontal lobe of depressed rats to play an antidepressant role. 2. 2. Isoquercetin has some brain protective effects, which may be related to its antidepressant mechanism.

    Studies on the biological activity of isoquercetin at home and abroad show that,IsoquercetinIts pharmacological action is remarkable, and its related preparations have broad prospects for development. However, for the development of isoquercetin related pharmaceutical preparations, solubility and stability are extremely important references in the development of new drug preparations.