Salvia miltiorrhiza is a commonly used traditional Chinese medicine, also known as red root, purple Salvia miltiorrhiza, blood ginseng root, etc., because its medicinal root is purplish red. Salvia miltiorrhiza Bge. Is the root and rhizome of Salvia miltiorrhiza Bge. Produced in Jiangsu, Anhui, Hebei, Sichuan and other places. Pick and dig in spring and autumn, wash and dry. Slice, segment, raw or stir fry with wine. The main effects are activating blood circulation and regulating menstruation, removing blood stasis and pain, cooling blood and eliminating carbuncle, clearing the heart and removing annoyance, nourishing blood and calming the mind. It can also improve the body's ability to tolerate hypoxia, prevent thrombosis, reduce blood lipids, protect the liver, resist tumor, reduce blood sugar and other effects. So what are the main ingredients that determine these effects of Salvia miltiorrhiza? The main active components of Salvia miltiorrhiza are salvianolic acid A and salvianolic acid B. the physiological activity of salvianolic acid A is better than that of salvianolic acid B. Salvia miltiorrhiza mainly has the effect of salvianolic acid a.
Salvianolic acid A has a wide range of pharmacological activities. It has a good preventive and therapeutic effect on cardiovascular and cerebrovascular diseases, liver fibrosis, diabetes, complications, tumors and other diseases, and its myocardial ischemia protection is better than salvianolic acid B. because oxidative stress plays an important role in the above diseases, the analysis of mechanism of action mostly believes that these pharmacological effects of salvianolic acid A are inseparable from its strong antioxidant activity. Because salvianolic acid A has multiple phenolic hydroxyl groups, it can reduce lipid peroxidation by scavenging free radicals, so as to improve the effect of oxidative stress on diseases. Based on the strong pharmacological activity of salvianolic acid A, the development of salvianolic acid A as an innovative drug for the prevention and treatment of cardiovascular and cerebrovascular diseases, diabetes and complications has become a hot spot, but its possible mechanism of action needs further research. The existing experimental results in our laboratory show that salvianolic acid A is not completely related to its antioxidant activity in the prevention and treatment of cardiovascular disease and diabetic complications. The activities of regulating mitochondrial function and inhibiting the production of inflammatory factors suggest that salvianolic acid A may play a role in multiple ways. Although the yield of salvianolic acid A has been significantly improved, most of the existing production processes are complex, difficult to industrialization and high production cost. Therefore, how to simplify the production steps under the requirements of ensuring the yield and purity is the main problem that needs to be paid attention to in the future. In addition, the pharmacokinetic characteristics of salvianolic acid A are not completely clear, and the selection of appropriate dosage form will also affect the absorption of salvianolic acid a.
With the comprehensive research on the chemistry, pharmacology and pharmacokinetics of salvianolic acid A, it is reasonable to believe thatSalvianolic acid AIt is expected to be developed for the prevention and treatment of cardiovascular and cerebrovascular diseases; It is an innovative drug with exact efficacy, safety and reliability in the aspects of diabetic complications.