Clinically, subarachnoid hemorrhage (SAH) is a serious neurosurgical emergency. Although the incidence of subarachnoid hemorrhage only accounts for 5% ~ 10% of the total incidence of stroke, the overall mortality accounts for 25% of the total mortality of stroke patients. In recent years, the research on the pathogenesis and pathophysiological process of subarachnoid hemorrhage has become increasingly in-depth, and various prevention and treatment measures have been widely carried out in clinical practice, which has made a certain improvement in its prognosis, but its mortality and disability rate are still high. Many patients have left permanent neurological deficit or cognitive impairment, and the clinical efficacy is not satisfactory. Studies have confirmed that secondary brain injury after subarachnoid hemorrhage is the main cause of poor prognosis. Therefore, effective prevention and treatment of secondary brain injury may be the key to improve the overall prognosis of subarachnoid hemorrhage.

    Angelica sinensis is one of the most frequently used medicinal plants in traditional Chinese medicine in China. It has been used for thousands of years. Artemisinin lactone is one of its main active ingredients. Artemisinin lactone has a wide range of pharmacological effects and has good clinical application potential and development value. Recent studies have proved that artemisinin lactone has neuroprotective effects on transient forebrain ischemia, permanent focal cerebral ischemia and permanent forebrain ischemia. It can also produce vasodilator effect on rat aorta or mesenteric artery by inhibiting calcium influx or calcium reservoir release, and can inhibit the proliferation of vascular smooth muscle and improve microcirculation. It was also found that artemisinin lactone has definite neuroprotective effect on subarachnoid hemorrhage model rats, which can improve neural function, reduce brain edema and permeability, and reduce neuronal apoptosis and necrosis.

    BecauseArtemisinin lactoneIt may alleviate the secondary cerebral ischemia injury caused by subarachnoid hemorrhage mainly through anti endothelial apoptosis to alleviate the delayed CSV after subarachnoid hemorrhage, anti free radical injury and anti neuronal apoptosis.