Astragalus membranaceus is the dry root of the leguminous plant Astragalus mongholicus or capsule Astragalus membranaceus. It tastes sweet and mild. It has the effects of Supplementing Qi and strengthening the exterior, diuresis and detoxification, astringent sores and invigorating qi and tonifying the middle. It contains coumarins, flavonoid saponins, trace folic acid and several vitamins. Astragalus saponins have a wide range of pharmacological effects. The effect of Astragaloside on cardiovascular system deserves our attention and utilization. So what are the outstanding effects of Astragalosides on the cardiovascular system?
FirstAstragaloside IIIIt can depressurize and dilate blood vessels
Studies have shown that astragaloside has obvious antihypertensive effect on anesthetized cats and can directly dilate blood vessels.
Second, astragaloside has cardiotonic effect
Some experiments have proved that small doses of astragaloside have negative inotropic effect, while medium and large doses can significantly improve various indexes of cardiac function of failing heart and have anti heart failure effect
Thirdly, astragaloside can protect myocardial cells
It has been found that 9% astragaloside a can improve the survival rate of mice with viral myocarditis, reduce collagen synthesis and myocardial apoptosis, which is safe and effective. Its anti apoptotic effect plays an important role in delaying or reversing myocardial fibrosis in viral myocarditis.
Fourth, astragaloside can improve the effect of heart preservation
The heart preservation solution containing astragaloside has good heart preservation function. It can protect the myocardial cell membrane and reduce the leakage of myocardial enzymes.
V. effect on cerebrovascular system
One of the causes of cell injury in cerebral ischemia is the formation of free radicals and lipid peroxidation. Intraperitoneal injection of astragaloside IV slightly increased glutathione peroxidase activity, but significantly decreased malondialdehyde content in ischemic brain tissue. It is suggested that there is obvious lipid peroxidation in ischemic brain tissue, and the potential antioxidant capacity of brain tissue is decreased.
Sixthly, effect on vascular endothelial cell permeability
The effect of Astragaloside on the increase of vascular endothelial cell monolayer permeability caused by histamine, an inflammatory mediator. Histamine can cause the increase of vascular endothelial monolayer permeability, while astragaloside can reduce the increase of endothelial monolayer permeability caused by histamine. Its mechanism needs further study
Seventh, influence on blood flow deformation
Erythrocyte deformability is an important factor affecting blood viscosity and fluidity. It was found that astragaloside Ⅱ, Ⅲ and Ⅳ can significantly improve the deformability of incubated erythrocytes
VIII. Anti biological oxidation
Ischemia-reperfusion injury is a common pathological process of many cardiovascular diseases, and free radical induced lipid peroxidation leads to biofilm damage. The experiment proved that Astragalus saponins could reduce lipid peroxidation and scavenge oxygen free radicals