Wogonin is a kind of flavonoids extracted from the root of Scutellaria baicalensis Georgi, a plant of Labiatae. Wogonin has attracted much attention because of its many pharmacological activities, including antioxidant activity, anti-inflammatory, immune regulation and so on. In addition, it has neuroprotective effect during cerebral ischemia. The following Xiaobian will review the four effects of wogonin.

    First, wogonin has antibacterial effect

    WogoninIt has a wide spectrum of bacteria resistance, and can inhibit Shigella, diphtheria, Pseudomonas aeruginosa, Staphylococcus, Streptococcus, Diplococcus pneumoniae and meningococcus. Throat spray with wogonin as the main component is also effective for meningitis carriers. Even Staphylococcus aureus, which has developed resistance to penicillin, is still sensitive to wogonin. It has been found that wogonin has significant antifungal activity at a concentration of 0.05%

    Second, wogonin has a protective effect on cardiovascular system

    Cardiovascular disease is the main cause of death in postmenopausal women. Hyperlipidemia is one of the important causes of cardiovascular disease. Hyperlipidemia refers to the high concentration of blood cholesterol, triglycerides and low-density lipoprotein, while the low concentration of high-density lipoprotein. Studies have shown that wogonin can significantly reduce the concentration of low-density lipoprotein and triglyceride content, and reduce the formation of thrombosis and the incidence of cardiovascular disease through the intervention of platelet and thrombin. At present, the mechanism of wogonin in cardiovascular disease can be summarized as follows: low density lipoprotein receptor regulation; Antioxidation; Inhibit the proliferation of vascular smooth muscle cells; Antithrombotic; Maintain vascular reactivity; Inhibition of cell adhesion; Change the activity of special growth factors involved in atherosclerotic plaque formation.

    Thirdly, wogonin has cholagogic and antispasmodic effects

    Wogonin has obvious inhibitory effect on the intestines in place. The experiment shows that wogonin has obvious antispasmodic effect.

    Fourthly, wogonin has anti-tumor effect

    (1) Inhibition of tumor cell proliferation

    The anti-tumor spectrum of flavonoids in Scutellaria baicalensis Georgi is extensive. A large number of studies have shown that Scutellaria baicalensis Georgi extract, baicalin, baicalein and wogonin can inhibit the proliferation of a variety of tumor cells in vitro. Wogonin can inhibit the growth of prostate cancer, bladder cancer, liver cancer, pancreatic cancer, malignant black tumor and cholangiocarcinoma cells. In recent years, the study on the mechanism of the inhibitory effect of wogonin on tumor in vitro shows that wogonin can inhibit the growth of normal cells with little effect. Wogonin can inhibit early leukemia cells. The in vivo experiment of wogonin also showed obvious antitumor activity.

    (2) The study of promoting tumor cell apoptosis showed that wogonin could induce ovarian cancer cell apoptosis and inhibit cell proliferation, and the inhibition was time and concentration dependent.

    (3) Affect tumor cell cycle

    Wogonin can reduce the expression of cyclin and cause cell cycle arrest

    (4) Anti angiogenesis

    Angiogenesis is a major cause of tumor overgrowth. Wogonin can significantly inhibit angiogenesis in embryoids to achieve the effect of anti angiogenesis.