SNCA
SNCA (Synuclein Alpha) is a gene that encodes the protein alpha-synuclein, a small, soluble protein predominantly expressed in neuronal presynaptic terminals. Alpha-synuclein is a key component of Lewy bodies, the pathological hallmarks of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy (collectively known as synucleinopathies). Mutations and duplications in SNCA are directly linked to inherited forms of Parkinson's disease, and its aggregation is central to the neurodegenerative process.
