| Catalog No | Package | Original Price | Price | Inventory | Quantity | Operating |
|---|---|---|---|---|---|---|
| BP4728-5mg | 5mg | $650.00 | Sign in |
|
Product name: Kuwanon W
Synonym name:
Catalogue No.: BP4728
Cas No.: 95518-95-9
Formula: C45H42O11
Mol Weight: 758.82
Botanical Source:
Type of Compound:
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams
Inquire for bulk scale.
For Reference Standard and R&D, Not for Human Use Directly.
Storage conditions：Short-term storage at 2~8℃, long-term storage at -20 ~ -80℃
Natural products, as an important source of drug discovery, play an irreplaceable role in the development of antitumor drugs. Kuwanon W is a natural flavonoid compound derived from the root parts of Morus lhou, a plant of the genus Morus, and has attracted widespread attention in recent years due to its remarkable biological activity. With the continuous rise in tumor incidence, the search for highly effective, low-toxicity anti-tumor drugs has become a key focus in contemporary drug development. With its unique chemical structure and multi-target mechanism, mulsoflavone W demonstrates promising application potential in the anti-tumor field. This paper systematically reviews the chemical structure and physicochemical properties of mulberry flavonoid W, plant origin and extraction methods, pharmacological activity, mechanism of action, druggability evaluation, and clinical application prospects, aiming to provide theoretical basis and reference for in-depth research and development of this natural product.
The molecular formula of mulflavonoid W is C_44H_58O_12, with a molecular weight of 758.82, making it a polyphenolic flavonoid derivative. Its structure is complex, containing multiple hydroxyl and methoxy substituents, and it exhibits high polarity and spatial conformational diversity. The LogP value of phesflavone W was 6.3075, indicating strong lipid solubility. This property helps it penetrate cell membranes but also suggests poor water solubility (0.0030 mg/mL), which may affect absorption and distribution in vivo. Its topological pole surface area (TPSA) is 198.12 Ų, and a higher pole surface area is usually associated with lower cell membrane permeability. The blood-brain barrier has low penetration capacity, suggesting its limited distribution in the central nervous system. Notably, mulflavone W does not inhibit hERG channels, and the Ames-induced mutagenic test result is 0.0, indicating high safety and low potential for cardiotoxicity and genotoxicity.
Mulsoflavone W mainly originates from the roots of the Morus lhou plant. Morus lhou belongs to the Moraceae family, widely distributed, and has traditionally been used as a medicinal herb in Asia. The extraction of mulflavone W typically uses organic solvent extraction combined with multi-step chromatography separation technology. The specific process includes:
In recent years, green extraction technologies such as ultrasound-assisted extraction and supercritical fluid extraction have also been applied to the extraction of mulsoflavone W, significantly improving extraction efficiency and purity, reducing solvent usage, and meeting the environmental requirements of modern natural product extraction.
Pharmacological activity studies of mulflavonoid W mainly focus on its antitumor effects. In vitro cell experiments have shown that mulflavonoid W has a significant proliferation inhibitory effect on various tumor cell lines, including breast cancer, lung cancer, liver cancer, and colorectal cancer cells. Its IC_50 values are usually in the low micromolar range and exhibit strong cytotoxicity.
Additionally, mulflavone W can induce tumor cell apoptosis, inhibit cell cycle progression, and block tumor cells' ability to migrate and invade. Animal model studies further confirmed its antitumor activity. In mouse transplanted tumor models, mulsoflavone W significantly inhibited tumor growth without significant toxic side effects.
In addition to its anti-tumor effects, sangflavone W also exhibits multiple biological activities including antioxidant, anti-inflammatory, and immunomodulatory properties, which may synergistically enhance its anti-tumor effects. Its anti-inflammatory activity helps block tumor progression by inhibiting inflammatory factor expression and reducing inflammatory responses in the tumor microenvironment.
The antitumor mechanism of mulflavone W involves multiple signaling pathways and molecular targets, reflecting its multi-target and multi-pathway pharmacological characteristics. The main targets include:
In summary, mulflavonoid W regulates tumor cell proliferation, apoptosis, migration, and microenvironment through multi-target synergistic effects, effectively inhibiting tumor occurrence and progression.
The druggability evaluation of mulflavone W shows that it poses certain challenges. High lipid solubility (LogP=6.3) and extremely high polar surface area (TPSA=198.12 Ų) result in extremely poor water solubility (0.0030 mg/mL), limiting its oral absorption and bioavailability. Additionally, the low permeability of the blood-brain barrier means it is difficult to treat central nervous system-related diseases.
However, muloflavone W does not inhibit hERG channels, reducing the risk of cardiotoxicity; A negative Ames test suggests low genotoxicity risk and good safety.
Currently, pharmacokinetic data on mulsoflavone W are relatively limited. Preliminary animal experiments indicate that it is slowly absorbed orally and has a long plasma half-life, possibly related to its high lipid solubility and large molecular weight. To improve its pharmacokinetic properties, drug delivery strategies such as nanocarriers, liposome encapsulation, and structural modification have been proposed to enhance bioavailability and targeting.
As a multi-target anti-tumor natural product, mulflavonoid W demonstrates good pharmacological activity and relatively high safety, showing great clinical application potential. It demonstrates unique advantages in the treatment of hormone-dependent tumors (such as breast cancer), solid tumors, and metastatic tumors.
Future research should focus on the following aspects:
In addition, the anti-inflammatory, antioxidant, and immunomodulatory effects of mulsoflavone W offer new application directions in adjuvant tumor therapy and chronic disease management.
As a natural flavonoid compound derived from the root of Morus lhou, mulflavonoid W has become a hot topic in natural product pharmacology research due to its unique chemical structure and multi-target antitumor activity. Its remarkable anti-tumor effects and good safety provide valuable resources for the development of novel anticancer drugs. Despite challenges in druggability such as poor water solubility and low bioavailability, with the development of modern drug delivery technologies and structural optimization strategies, mulflavonoid W is expected to break through bottlenecks and enter clinical application. In the future, through multidisciplinary collaboration to deeply explore its mechanisms of action and clinical potential, Thasflavone W is expected to become an important member of the antitumor drug field, advancing natural product drug development to new heights.
