On December 26, the founding ceremony and academic seminar of the international glycomics research center / international polysaccharide research center were held in Shanghai International Medical Park. The project is jointly constructed by Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Shandong Zaozhuang new ZTE Co., Ltd. to develop the research and development of precise diagnosis and treatment of caramel science.

Chenkaixian, academician and pharmaceutical chemist of the Chinese Academy of Sciences, Peigang, academician and cytobiologist of the Chinese Academy of Sciences, Dingjian, academician of the Chinese Academy of engineering, academician of the Academy of Sciences of developing countries and Dean of the school of pharmacy of the University of the Chinese Academy of Sciences, zhangyukui, academician of the Chinese Academy of Sciences and researcher of the basic theory, new technology and new methods of chromatography, Zhang Lina, academician of the Chinese Academy of Sciences, professor and doctoral supervisor of Wuhan University, huangtieqing, deputy director of the major tasks Bureau of the Chinese Academy of Sciences, Yu Shanjiang, director of the policy coordination Office of the biotechnology development center of the Ministry of science and technology of China, Ding Kan, researcher of the Shanghai Institute of pharmacy of the Chinese Academy of Sciences, caohongming, director of the biomedicine Office of the Shanghai Municipal Science and Technology Commission Director Wujun, deputy secretary of the Party committee of Shanghai Zhangjiang (Group) Wangkairong, chairman of Shanghai International Medical Park Group Co., Ltd., Zhang Feng, director of Zaozhuang food and drug administration, songhaifang, deputy head of Zaozhuang Shizhong District government, chairman of Zaozhuang new ZTE Co., Ltd General manager liuxuedian, party secretary Jinling and other leaders and guests attended the unveiling ceremony.

  Prospects and challenges of sugar Science

Polysaccharide is one of the most abundant substances in nature. It widely exists in animal cell membrane, plant and microbial cell wall. It is a kind of biological macromolecule closely related to human life and plays an important role in maintaining life activities. In recent years, a large number of studies have shown that polysaccharides have many biological functions, such as immune regulation, hypoglycemic, hypolipidemic, anti-tumor, anti-virus, anti-oxidation, anti-aging, anti coagulation, anti ulcer, anti radiation and so on. With the development of glycomics and glycobiology, as well as the improvement of the methods of separation and purification, structural analysis, qualitative and quantitative analysis of sugars, more and more sugars with good pharmacological activity and safety have entered the vision of sugar scientists and pharmacists. At present, mannan oligosaccharide diacid (gv-971), a new drug for the treatment of Alzheimer's disease (AD) jointly developed by Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Ocean University of China and Green Valley pharmaceutical, is the latest achievement in the research and development of carbohydrate drugs.

Although more and more attention has been paid to the study of polysaccharides, the study of polysaccharides is also facing many problems due to the complex structure and diverse functions of sugars, the inability of sugar chains to be synthesized and sequenced at will like nucleic acids and proteins, and the lack of big data support of glycomics.

Academician Chen Kaixian said: "exploring the basic scientific issues of the interaction between sugar chain, disease and medicine has become a major scientific proposition in the frontier field of life science. Sugar substances have complex structures and diverse functions, which meet the needs of the treatment standards for complex diseases and are expected to lead the innovation frontier in the treatment of complex diseases."

  Two "centers" were established to help the development of sugar Science

According to the introduction, the international glycomics research center / the international polysaccharide research center will develop new concepts, strategies, technologies and methods in the field of sugar science through international cooperation, focusing on the function, biological activity, efficacy relationship and action mechanism of glycomics and polysaccharides in tumors, neurodegenerative diseases and metabolic diseases; By using glycomics, Glycochemistry and glycobiology technologies, we study the structure, function and biosynthesis of sugar chains of glycans, glycoproteins and proteoglycans in the physiological and pathological processes of life, find another way for the precise prevention and treatment of major diseases, promote the development of international sugar science, lay a solid foundation for human health, provide sugar science, technology and knowledge services for domestic and foreign scientific research institutions, enterprises, the public and sugar scientists, and build an academic exchange and research platform in the field of glycomics and polysaccharides.

Li Jia, deputy director of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, said: "China is a large country of carbohydrate resources, and has made important progress in the chemical synthesis of polysaccharides and the research on sugars related to the efficacy of traditional Chinese medicine compounds. In particular, the recent successful completion of the third phase of anti Alzheimer's disease clinical trial of gv-971, the world's first therapeutic and marine oligosaccharide drug for AD, has played a driving role in leading the international research on carbohydrate drugs, overcoming the difficult problems in the treatment of complex diseases in the world, and improving the research and development of innovative drugs in China. The Shanghai Institute of Materia Medica of the Chinese Academy of Sciences will always adhere to the spirit of continuous innovation, aim at the frontier fields of international life science development and important scientific issues of drug research, carry out basic and applied research on innovative drugs, develop new theories, new methods and new technologies of drug research, and make efforts for the construction of the center. "

Liuxuedian, chairman and general manager of Zaozhuang new ZTE, said: "scientific and technological innovation is the golden key to opening the door to health. Zaozhuang new ZTE has continuously adjusted the industrial structure and innovated the mechanism and system in the transformation of old and new driving forces, vigorously promoted the development of green industry with the construction of science base as the carrier, and actively explored a new way to closely integrate science, technology and industry. Wurong planting base has realized the transformation from planting to processing of series products, and its products have entered 17 local markets inside and outside the province. The Wurong planting and processing project is a work that conforms to the concept of building a "healthy China" advocated by the state. It is a successful move of close connection between industry, University and Research Institute, in-depth integration, and each shows its advantages. It is also a practical model for all parties to work together to quickly convert scientific research results into productivity and form a real economy industry. We will take the establishment of the international polysaccharide research center as an opportunity to give full play to our own advantages, strengthen the integration of capital and projects, promote the collaborative innovation of science and technology and industry, achieve the deep integration of innovation chain and industry chain, accelerate the industrialization of high-end biopharmaceuticals, create a new highland of biomedical science and technology, and make due contributions to the construction of a beautiful and healthy China based on the principles of long-term cooperation, mutual benefit and common development! "

  Linked Zhangjiang Science City to build an international polysaccharide / glycome Research Center

With regard to the establishment of the international glycome Research Center / international polysaccharide Research Center, wangkairong, deputy secretary of the Party committee of Shanghai Zhangjiang (Group) and chairman of Shanghai International Medical Park Group, said at the unveiling ceremony: "at present, Zhangjiang Science City and Shanghai International Medical Park are closely focusing on building a core bearing area for the development of Shanghai health service industry and the landmark brand of Shanghai Asian Medical Center for external services, including building a first-class tumor medical center in Asia, building a clinical trial hospital, promoting the high-quality development of a third-party medical laboratory, and building a whole industry chain of cell therapy from storage, R & D, production, transportation to treatment. The settlement of the international glycomics research center / international polysaccharide research center in Shanghai International Medical Park will open up a new path for Zhangjiang Science City in the field of innovative research and development of polysaccharide drugs, create a new peak, and bring new hope for the treatment of a variety of diseases. "

Academician chenkaixian said: "the center will base itself on the Shanghai International Medical Park, strive to establish a world-class sugar science and sugar drug research and development center, try to strengthen cooperation with other international countries, and contribute to the research of polysaccharides, glycoproteins and proteoglycans in a Chinese way."

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