1、 Pharmacopoeia standard of dannanxing
This product is processed from the fine powder of tiannanxing and the bile of cattle, sheep or pigs, or it is fermented from the fine powder of tiannanxing and the bile of cattle, sheep or pigs.
[properties] the product is square or cylindrical. Brownish yellow, grayish brown or brownish black. Hard quality. .
[identification] (1) the powder of this product is yellowish brown. Parenchyma cells were round like and filled with gelatinized starch granules. The length of calcium oxalate needle crystal bundle is 20 ～ 90 μ M. The diameter of threaded conduit and annular conduit is 8 ～ 60 μ M.
(2) Take 0.2g of this product powder, add 5ml of water, shake, filter, take 2ml of filtrate and put it into a test tube, add 0.5ml of newly prepared furfural solution (1 → 100), add 2ml of sulfuric acid along the tube wall, and the junction of the two liquids will show a brownish red ring.
[nature, taste and meridian tropism] bitter, pungent and cool. .
[functions and indications] clearing heat and resolving phlegm, calming wind and calming shock. It is used for cough due to phlegm heat, yellow and thick expectoration, stroke, phlegm confusion, and epilepsy.
[usage and dosage] 3 ～ 6G.
[storage] store in a ventilated and dry place to prevent moths.

2、 Chemical constituents of Gentiana scabra l.var.cholerae l.var.cholerae l.var.cholerae l.var.cholerae l.var.cholerae l.var.cholerae l.var.cholerae

It contains alkaloids, a variety of amino acids, triterpenoid saponins, benzoic acid, starch, etc.

3、 Pharmacological effects of dannanxing

1. anticonvulsant effect: intraperitoneal injection of konjaku decoction can improve the electric convulsion valve of rabbits, but can not prevent the maximum electric shock attack in mice or rats. Intraperitoneal injection of konjaku water extract in mice can significantly reduce the convulsion rate and mortality of strychnine, and can reduce the convulsion rate caused by pentylenetetrazol and caffeine in mice, but it has also been reported; Tiannanxing (unidentified variety) could not resist the convulsion and death caused by strychnine, but could resist the convulsion and death caused by nicotine, and could partially eliminate its muscle tremor symptoms; However, for convulsions caused by tetanus toxin intramuscular injection in mice, tiannanxing can delay the time of animal death. The above results showed that different varieties of tiannanxing had different anti startle effects.

2. sedative and analgesic effects. After intraperitoneal injection of tiannanxing decoction, rabbits and rats showed decreased activity, quiet and blunted righting reflex. It can significantly prolong the sleep time of pentobarbital sodium in mice. The hot plate method in mice shows that this product (not signed) has obvious analgesic effect.

.

4. antiarrhythmic effect. In recent years, it has been found that the diketopiperazine alkaloids of Rhizoma callicarpae can resist experimental arrhythmias caused by aconitine, and the chloroform part of it has a more significant effect, and can prolong the effective refractory period of action potential of cardiomyocytes.

; It is also effective against experimental tumors in mice, such as sarcoma S180, HCA solid type, U14, etc., and it is proved that D-Mannitol may be an effective anti-cancer ingredient.

6. side effects: raw Nanxing is toxic. Ingestion of the poison can cause burning sensation of throat, numbness of mouth and tongue, mucosal erosion, edema, salivation, difficulty in opening mouth, and suffocation in severe cases; ; Some can cause mental retardation.