1、 Pharmacopoeia standard of Folium Lycii
This product is the dried leaves of Ilex cornuta lindl.ex paxt. Harvest in autumn, remove impurities and dry in the sun.
[properties] this product is quasi rectangular or rectangular in shape, occasionally long oval, 3-8cm long and 1.5-4cm wide. It has three large hard thorns at the apex, one at the top is often recurved, the base is flat cut or wide wedge-shaped, and sometimes has 1-3 thorns on both sides, and the edge is slightly inverted; Long oval leaves often have no thorny teeth. The upper surface is yellowish green or greenish brown, shiny, and the lower surface is grayish yellow or grayish green. Leaf veins pinnate, petioles shorter. Leather, hard and thick. The breath is slight, and the taste is slightly bitter.
[identification] (1) the transverse section of the leaf near the base of this product: the upper epidermal cells are square, the wall is thick, the outer layer is thick, and there are single-cell non glandular hairs at the main vein; . Palisade tissue consists of 2-4 rows of cells and spongy tissue is loose; In the upper and lower epidermis of the main vein, there are 1 to several rows of pachytene cells. The vascular bundle of the main vein is tough outside, and there are lignified fiber groups above and below it. In the epidermis of leaf margin, there are thick horn cells and stone cell semicircular bands, and then there are lignified fiber groups; There are only a few rows of pachytene cells at the leaf margin near the petiole, and there is no pachytene tissue near the base. Stone cells were occasionally found in the sclerenchyma within the epidermis of the leaf margin and the lower epidermis at the main vein, and also occasionally outside the fiber group below the phloem. Parenchyma and lower epidermal cells often contain calcium oxalate clusters.
(2) . Another 2G of the control medicinal material of Folium Lycii was taken and made into the control medicinal material solution by the same method. According to the test of thin-layer chromatography (general rule 0502), suck 1 μ l of each of the above two solutions, dot them on the same silica gel G thin-layer plate, use chloroform ethyl acetate methanol water (1:3:1:0.3) as the developing agent, develop, take out, air dry, spray 10% sulfuric acid ethanol solution, heat at 105 ℃ until the spots are clear. .
[inspection] the moisture content shall not exceed 8.0% (the second method of general rule 0832).
The total ash content shall not exceed 6.0% (general rule 2302).
[nature, taste and meridian tropism] bitter and cool. Return to liver and kidney channels.
. It is used for tuberculosis, hemoptysis, bone steaming, hot flushes, dizziness and dizziness.
[usage and dosage] 9 ～ 15g
[storage] put it in a dry place.

2、 Chemical constituents from leaves of Lycium barbarum

containLupeol, 3,28-ursolic acid diolUrsolic acid, isorhamnetin, kaempferol-3-o - β - D-glucoside, quercitrin-3-o - β - D-glucosideIsorhamnetin-3-o - β - D-glucoside, ileoside II. It also contains caffeine,Carotene, sanguiside Ⅰ andSanguisorba glycosideⅡ, Kudingcha glycoside aKudingcha glycosideB、Kudingcha glycosideC andKudingcha glycosideD， Kudingcha glycolipid A andKudingcha glycolipidB, 3,4-dicaffeoylquinic acid,Isochlorogenic acid A, adenosine, Lycium saponin I methyl ester, Lycium saponin II, 29 hydroxyoleanolic acid-3-o-l-arabinopyranosyl-28-o-d-glucopyranoside, neolignan, namely 2- (3-methoxy-4-hydroxyphenyl) - 3-hydroxymethyl-7-methoxybenzofuran-5-methyl acrylate, and pomonol-3-o-l-2-acetoxyarabinopyranosyl-28-o-d-glucopyranoside, which can promote the formation of prostaglandin I2 (PGI2).

3、 Pharmacological effects of Folium Lycii

① After perfusing the isolated guinea pig heart, Gougu injection (an aqueous solution treated with ethanol and nahso2) can increase its coronary flow and strengthen cardiac contractility.

② Contraception
The water and alcohol extracts of Lycium barbarum or other related preparations given to mice by gavage can reduce pregnancy, and the pregnancy inhibition rate is 80-100%; Vaginal smears proved that Gougu can change the normal sexual cycle of mice, mainly by prolonging the rest period, and secondly by exceeding or shortening the estrous period. The alcohol extract (green powder with glycoside reaction) of the leaves of Lycium barbarum has contraceptive effect. .