Croton cream
1、 Pharmacopoeia standard of Croton cream       This product is processed from Croton.
      [preparation method] take Croton kernels and make the cream according to the frost making method (general rule 0213), or take the kernels and grind them fine, and then determine the content of fatty oil according to the method under [content determination], add an appropriate amount of starch, make the content of fatty oil meet the requirements, and mix well.
      [properties] this product is a light yellow powder with uniform particle size and loose, which is oily.
      . Endosperm cells are round, containing fat oil droplets, aleurone particles and calcium oxalate crystals.
      (2) Take this product, according to Croton [identification] (2) tests, showing the same results.
      [check] moisture   .
      Total ash   .
      [content determination] fatty oil   .
      The fatty oil content of this product should be 18.0% - 20.0%.
      ; Determine according to high-performance liquid chromatography (general rule 0512).
      Chromatographic conditions and system suitability test   Octadecylsilane bonded silica gel was used as filler; The mobile phase was acetonitrile methanol water (1:4:95); .
      Preparation of reference solution   .
      Preparation of test solution   Take about 0.15g of this product, accurately weigh it, put it in Soxhlet extractor, add 50ml of ether, heat it for reflux for 3 hours, discard the ether solution, volatilize the solvent from the drug residue, and move it together with the filter paper cylinder into a corked conical bottle, precisely add 50ml of water, weigh it, sonicate (power 300W, frequency 24khz) for 20 minutes, cool it, weigh it again, make up the lost weight with water, shake it evenly, filter it, and then get it.
      Assay   Precisely suck 10 μ l of the reference solution and 10 μ l of the test solution respectively, inject them into the liquid chromatograph, and determine.
      According to the calculation of dry product, the content of crotonoside (c10h13n5o5) shall not be less than 0.80%.
      [nature, taste and meridian tropism] pungent, hot; It is highly toxic. Return to stomach and large intestine.
      [functions and indications] cool accumulation under the body, expel water to reduce swelling, eliminate phlegm and facilitate swallowing; Erosion sores for external use. It is used for constipation due to cold accumulation, stagnation of milk and food, distention of ascites, obstruction of two stools, laryngeal wind and throat obstruction; .
      [usage and dosage] 0.1 ~ 0.3g, multi entry pill powder. Appropriate for external use.
      [note] it is forbidden for pregnant women; It should not be used with Petunia.
      [storage] store in a cool and dry place.


2、 Chemical constituents of Croton cream
Contains croton oil, including glycerides of oleic acid, linoleic acid, Croton oleic acid, CIS angelic acid, etc; Still containCrotonoside。

3、 Pharmacological effects of Croton cream
1. it has strong irritating effect on skin mucosa and digestive tract. It has excitatory effect on intestinal muscles. It can produce severe diarrhea and induce vomiting.

2. it has analgesic effect. PMA, the active ingredient in croton oil, is a powerful platelet agglutinant.

3. Croton contains cancer promoting ingredients, but it also contains anticancer active substances.

4. the decoction has certain inhibitory effect on Staphylococcus aureus, diphtheria bacilli, influenza bacilli, etc.