IsoliquiritigeninIt has anti-tumor, anti-oxidation, anti-inflammatory and other effects, can dilate arteries, and has a protective effect on the heart and brain. The anti-tumor effect of isoliquiritigenin is a very important pharmacological effect. It is mainly realized through the following three points:

    1. inhibition of cancer inducers and cancer promoters

    It is reported that isoliquiritigenin can inhibit the carcinogenic effect of carcinogens, among which 12-o-tetradecanoyl phorbol acetate -13  (TPA)、 7-bromotoluene-a-anthracene (brmba), azoxymethane (azoxymethane) and cadmium can induce tumor. Babam et al. Induced the mouse variant colon glandular fossa lesion model with oxyazomethane, which also proved that isoliquiritigenin may be a potential chemopreventive agent for colon cancer. Kimsc et al reported that isoliquiritigenin can inhibit the translocation of bad to mitochondria, reduce the expression of BAL (XL) and cytochrome C in mitochondria, and reduce the clearance of poly (ADP ribose) polymerase, so as to achieve its effect on cadmium   (CD) induced the protective effect of apoptosis.

    2. anti proliferation and inducing apoptosis of cancer cells

    Apoptosis, also known as programmedcelldeath, is an active cell suicide. Under normal circumstances, there is a balance between cell proliferation and apoptosis. Once this balance is destroyed, it may lead to tumorigenesis. The use of drugs to induce tumor apoptosis is also a hot spot in oncology research in recent years. Maj et al. Found that isoliquiritigenin could increase calcium concentration and decrease mitochondrial membrane potential, and induce apoptosis of gastric cancer MGC-803 cells. Maggiolinim et al. Found that isoliquiritigenin not only has anti-tumor activity, but also can promote the growth of breast cancer through estrogen receptor α dependence. The study found that the anti proliferation effect of isoliquiritigenin is bidirectional: at low and medium concentrations, it has transcriptional activity, which can stimulate the proliferation of MCF-7 cells; However, high concentrations of isoliquiritigenin have cytotoxicity, even in HeLa cells insensitive to steroid hormone receptors.

    3. inducing tumor reversal

    Isoliquiritigenin significantly inhibited the proliferation of tumor cells, but did not kill tumor cells. After treatment with isoliquiritigenin for 72 hours, HL-60 cells had smaller nuclei, smaller nucleoplasm ratio, kidney shaped nuclei, dense and thick chromatin, and reduced or disappeared nucleoli Isoliquiritigenin can reverse the malignant phenotype of tumor cells and make tumor cells differentiate into normal cells again