Kebanning mainly exists in the tubers of Stephania and other plants in Yunnan. It is commonly known as "mountain Tortoise" in the folk. Kebanning belongs to the alprofei type alkaloid. Studies have proved that it has a strong antagonistic effect on a variety of experimental arrhythmias. The compound also has sedative, analgesic, antispasmodic, anticonvulsant and other effects. It is a bioactive substance worthy of further research and development.
In the process of myocardial ischemia-reperfusion, many factors participate in myocardial injury and induce arrhythmia, among which the production of oxygen free radicals is one of the important reasons. Ischemia-reperfusion causes the increase of a large number of oxygen free radicals and intracellular calcium overload, which reduces the activity of the enzyme (SOD) that scavenges oxygen free radicals and the activity of glutathione peroxidase, leads to the accumulation of oxygen free radicals, increases the content of malondialdehyde (MDA), the membrane lipid peroxidation product, and accelerates the degree of myocardial cell damage. Cause membrane bioelectric instability,KebanninIt can significantly reduce the content of MDA in myocardial tissue and increase the activities of SOD and GSH Px, which may be an important mechanism for it to resist the occurrence of ischemia-reperfusion arrhythmia, reduce the incidence of VT and VF, delay the occurrence time and shorten the duration of arrhythmia, reduce myocardial injury caused by reperfusion, and reduce the area of myocardial ischemia and the extent of infarction.
Because of their huge massive roots, mountain turtles are easy to survive and have high yields. They can also provide the necessary drug resources by means of variety optimization, tissue culture and other methods, so as to facilitate the rational development and utilization of natural resources. In order to give full play to the advantages of green resources and promote local economic development, it is necessary to develop, research and utilize these drug resources. The in-depth study on the anti myocardial ischemia and cardiovascular effects and mechanisms of kebanning will also help to further develop the application of isoquinoline compounds in cardiovascular diseases.