Rhododendron has the effects of relieving cough, eliminating phlegm and relieving asthma. It is mainly used to treat acute and chronic bronchitis, asthma and other diseases. Pharmacological experiments show that,RhododendronIt has a clear expectorant effect. It can directly act on the respiratory mucosa, promote ciliary movement, enhance the mechanical removal of foreign bodies in the trachea and bronchus, break the acid glycoprotein fiber in the sputum, reduce the content of sialic acid, reduce the viscosity of the sputum, dilute the sputum, easy to cough up, and gradually reduce the amount of sputum. The expectorant effect on patients with chronic tracheitis is definite, the curative effect is lasting and stable, and the amount of sputum is significantly reduced, the viscosity is reduced, and the symptoms are reduced. Clinically, it is mainly used for phlegm caused by chronic bronchitis.

    However, due to the poor water solubility of Rhododendron, its bioavailability is low when taken orally, which affects its therapeutic effect. For poorly soluble compounds, drug dissolution is often the rate limiting step affecting their absorption. Improving the solubility and dissolution rate of poorly soluble drugs is often the primary problem to be solved to improve their oral bioavailability.

    Solid dispersion technology is one of the effective methods to improve the oral bioavailability of insoluble drugs, and has made great progress in recent years. Solid dispersion system refers to the dispersion system formed by the uniform dispersion of drugs in a carrier material in amorphous, colloidal, molecular, microcrystalline and other states. As a new technology of pharmaceutical preparations, solid dispersion is mainly used to change the dispersion state of insoluble drugs in its preparations, so as to improve the solubility and dissolution of drugs and improve the bioavailability of drugs. Therefore, the effect of improving the bioavailability of azaleas can be achieved by solid dispersion treatment of azaleas, but azaleas have a better effect on human body.